A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five-year survival rate. PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair...
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Researchers identify interaction among proteins that cause cancer cells to metastasize
Electron microscopic image of a single human lymphocyte. Researchers at Mayo Clinic have identified an interaction among proteins that allows cancer cells to grow and metastasize. They say the discovery may play a role in developing a better understanding of how tumors grow in a variety of malignancies, including breast, prostate, pancreatic, colon, lung...
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Researchers show p300 protein may suppress leukemia in MDS patients
MIAMI, March 27, 2017 – Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). The study was published in the journal Leukemia....
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Single-cell analysis reveals subtypes of colorectal tumors
Cancer — Histopathologic image of colonic carcinoid. Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory (JAX), has defined cell-type composition of cancerous cells from 11 colorectal tumors, as well as adjacent noncancerous cells, a key to more targeted diagnosis and treatment....
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AI that detects cancer in blood and pinpoints its location before symptoms appear ‘could be ready in one year’
Scientists from the University of California developed the new software It works by looking for specific molecular patterns in cancer DNA The algorithm was able to correctly detect cancer in 80 per cent of cases A machine that can detect cancer from a blood sample could be ready in a year. Scientists in California have developed a computer program that...
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X-Rays Of The Earliest Stage Of Alzheimer’s Offer Critical Clue About How It Starts
Scientists peered into the brains of mice and saw something about Alzheimer’s they hadn’t seen before. As many as 5 million Americans are living with Alzheimer’s disease today, and that number could more than triple by 2025. The brain disorder is the most common form of dementia, causing memory loss that worsens over time and eventually pushes the...
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MRI use may “change the equation” for prostate cancer screening
Screening for prostate cancer is controversial. It can save lives, but it can also lead to unnecessary diagnoses, followed by surgical or radiation procedures, which themselves may lead to severe side-effects. Now a new study, coming from the Dutch part of the European Randomised study for the Screening of Prostate Cancer (ERSPC) has found that...
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Tree nut allergy: Avoiding all tree nuts ‘may not be necessary’
More than half of patients who test positive for tree nut allergies based on blood or skin prick assessments experience no reaction to the nuts when consumed, a new study finds. New research suggests that an oral food challenge should be used to confirm tree nut allergies. Lead study author Dr. Christopher Couch, a...
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Researchers find biomarker that could help predict the onset of type 1 diabetes
A significant finding has been made by the 3U Diabetes Consortium, of Dublin City University, Maynooth University and the Royal College of Surgeons in Ireland (RCSI), which has the potential to contribute to the identification of biological markers that predict the development of Type 1 diabetes, a chronic autoimmune disease. The findings, which have been...
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Scientists report genetic test to help predict men at most risk from aggressive prostate cancer
Scientists are reporting a test which can predict which patients are most at risk from aggressive prostate cancer, and whether they suffer an increased chance of treatment failure. This test, reported at the European Association of Urology conference in London, and published in the Journal of the National Cancer Institute, may give men a better view...