Abstract Cerebral Palsy (CP) is a disabling condition that affects a child’s life and his/her family irreversibly. It is usually a non-progressive condition but improvement over time is rarely seen. The condition can be due to prenatal hypoxia, metabolic, genetic, infectious, traumatic or other causes. It is therefore a heterogeneous group that results in functional...
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Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ Stem Cells
Abstract Aim. CD133+ stem cells bear huge potential for regenerative medicine. However, low retention in the injured tissue and massive cell death reduce beneficial effects. In order to address these issues, we intended to develop a nonviral system for appropriate cell engineering. Materials and Methods. Modification of human CD133+ stem cells with magnetic polyplexes carrying microRNA was studied...
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Mesenchymal Stem Cell Administration in Patients with Chronic Obstructive Pulmonary Disease: State of the Science
Abstract Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible airway inflammation; currently, there is no effective or curative treatment and the main goals of COPD management are to mitigate symptoms and improve patients’ quality of life. Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung...
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Spherical biodegradable carriers support scalable and cost-effective stem cell expansion and bone formation
Stem cells (red) on polycaprolactone-based microcarriers. Bone tissue engineering is theoretically now possible at a large scale. A*STAR researchers have developed small biodegradable and biocompatible supports that aid stem cell differentiation and multiplication as well as bone formation in living animal models. Mesenchymal stem cells self-renew and differentiate into fat, muscle, bone, and cartilage cells, which makes them...
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Stem Cells Applications in Regenerative Medicine and Disease Therapeutics
Abstract Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by...
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Cancer cells disguise themselves by switching off genes, new research reveals
Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body. In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a...
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Anti-cancer drug gets a boost when combined with antirheumatic
The figure shows a close-up of the histone protein region of a nucleosome core particle in which two different drugs (auranofin and RAPTA-T) are bound. Scientists at EPFL and NTU have discovered that combining an anticancer drug with an antirheumatic produces improved effects against tumors. The discovery opens a new path for drug-drug synergy....
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Deworming pill may be effective in treating liver cancer
Metastatic hepatocellular carcinoma. Hepatocellular carcinoma (HCC), a cancer associated with underlying liver disease and cirrhosis that often only becomes symptomatic when it is very advanced, is the second leading cause of cancer deaths around the world, and yet it has no effective treatment. As with other conditions without treatments, the data that scientists need...
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Immunologic changes point to potential for clinical investigation of combination immunotherapy for deadly kidney cancer
Immunologic changes observed in an early study of patients with metastatic renal cell carcinoma (MRCC) raised the possibility for a larger clinical study of combination immunotherapy, according to findings reported by researchers at The University of Texas MD Anderson Cancer Center. The results of an open-label pilot study comparing combinations of anti-PD1 (nivolumab) alone, or...
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The ‘triple threat’ cancer capsule that can navigate itself towards tumours before exploding and releasing drugs
The drug is wrapped in a microcapsule that can navigate towards cancer cells Millions of these tiny capsules could be injected into the bloodstream The outer layer of the capsule would prevent damage to healthy tissue Using an ultrasound machine, doctors could trigger the microcapsules to rupture when they reach a solid tumor, releasing the...