University of Wyoming Professor Jonathan Fox, in the Department of Veterinary Sciences, leads research that has found a link between excess mitochondrial iron and Huntington’s disease. Credit: University of Wyoming Scientists at the University of Wyoming have found that mice engineered to have Huntington’s disease (HD) have an over-accumulation of iron in their mitochondria. The...
Post
Novel combination therapy effective for NRAS mutant and therapy resistant melanoma
Wistar researchers have identified a novel therapeutic vulnerability in NRAS mutant melanoma and an effective strategy to address it, using a combination of two clinically relevant inhibitors, according to study results published online in EMBO Molecular Medicine. NRAS mutant melanoma represents about 25 percent of melanoma cases. The prognosis for patients is generally poor because NRAS...
Post
Augmented reality app may aid patients with Parkinson’s
Rice engineering students have designed an iPhone app to help patients overcome a symptom known as “freezing,” in which the legs temporarily refuse to follow the brain’s command to lift and move forward. In visual mode, the app places It’s appropriate that during Parkinson’s Awareness Month, a team of Rice University seniors will show how...
Post
Anti-epileptic drugs increase the risk of bone fractures in children
New research has shown evidence that anti-epileptic drugs (AEDs) reduce bone density in children and therefore lead to an increase in the number of fractures if used for more than a year. The study by the Murdoch Children’s Research Institute (MCRI), in conjunction with the Royal Melbourne Hospital (RMH), has prompted experts to highlight the...
Post
Scotland: Direct-acting antiviral agent therapy reduces the burden of HCV-related decompensated cirrhosis
Two presentations given this week at The International Liver Congress 2018 in Paris, France illustrate the impact that DAAs can have in averting HCV-related liver disease and reducing the clinical and economic burden of this chronic infection. The first presentation summarized data from Scottish national records providing country-level evidence of a reduction in HCV-related decompensated...
Post
First real-world studies report glecaprevir/pibrentasvir to be effective and well tolerated in chronic HCV infection
The results of the first real-world studies assessing the effectiveness and safety of glecaprevir/pibrentasvir (G/P) in patients with chronic hepatitis C virus (HCV) infection have confirmed high rates of viral suppression and a favourable safety profile in patients receiving 8-16 weeks of treatment. Two real-world studies from Italy and Germany which will be presented at...
Post
Researchers are one step closer to an effective anti-atherosclerosis vaccine
As the cardiovascular disease progresses, the proportion of protective Tregs decreases. Credit: Dr. Klaus Ley, La Jolla Institute for Allergy and Immunology In the disease atherosclerosis, cholesterol-containing plaques form in vessel walls, causing arteries to narrow and greatly increasing the risk of heart attack and stroke. Currently, atherosclerosis is the number 1 killer worldwide, just...
Post
Bad antibodies made good: The immune system’s secret weapon uncovered
The ‘bad apples’ of the immune system are also its secret weapon, according to major Australian research published today in the world-leading journal Science. In a world first, scientists from Sydney’s Garvan Institute of Medical Research have revealed how a population of ‘bad’ antibodies in the immune system – which are usually ‘silenced’ because they can...
Post
Immunotherapy provides long-term survival benefit: Further evidence in lung cancer
European Lung Cancer Congress (ELCC 2018) Lugano-Geneva, 12 April 2018 – Further evidence that immunotherapy provides long-term survival benefit for patients with lung cancer was presented today at ELCC 2018 (European Lung Cancer Congress) in Geneva, Switzerland. (1) Researchers presented the three-year survival results of the randomized phase 2 POPLAR trial in second line, (2)...
Post
Continuous glucose monitors proven cost-effective, add to quality of life for diabetics
Study of patients with type 1 diabetes shows that use of a continuous glucose monitor improves glucose control, adds to the quality of life, and is cost-effective over manual testing with strips IMAGE: NEWER MODELS OF CONTINUOUS GLUCOSE MONITORS CAN TRANSMIT DATA TO SMARTPHONES AND SMARTWATCHES Continuous glucose monitors (CGM) offer significant, daily benefits to people...