Older adults who take a novel antioxidant that specifically targets cellular powerhouses, or mitochondria, see age-related vascular changes reverse by the equivalent of 15 to 20 years within six weeks, according to new University of Colorado Boulder research. The study, published this week in the American Heart Association journal Hypertension, adds to a growing body of evidence suggesting...
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Chromosomal Instability Drives Cancer Metastasis
Image: When a chromosomally unstable cell divides, its chromosomes can become disordered during anaphase (1). Errors in segregation can allow chromosomes to leak into the cytosol, where they form “micronuclei” (2), which trigger an inflammatory response in the daughter cell (3). This response can lead to metastasis. EDITOR’S CHOICE IN ONCOLOGY Aneuploidy—the presence of abnormal numbers...
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New Ovarian Cancer Vaccine Shows Promise
Ovarian cancer is a particularly hard-to-treat disease. It’s often diagnosed late, and even after surgery and chemotherapy, around 85 percent of patients relapse and develop chemoresistance. But a preliminary clinical trial, carried out by researchers at the University of Pennsylvania, has shown promising results for a new type of vaccine that aims to boost patients’ immune systems...
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Cell Droplets Proteins and RNA aggregate into “membraneless organelles” due to liquid-liquid phase separation
Proteins gather and separate into droplets in the nucleus of a HeLa cell.T NOTT ET AL. Phase separation—the process of converting a solution into its constituent liquids—may explain how living cells keep the molecules within them apart. When a group of protein or RNA molecules gathers together in a high enough concentration, physical forces can...
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Nanobot Schematic
Schematic of a helix-shape nanorobot moving through a living cellMALAY PAL For the first time, scientists have inserted a helix-shape nanorobot inside a living cell and successfully manipulated it with magnetic fields. Ambarish Ghosh, a biophysicist at the Indian Institute of Science in Bangalore, and colleagues designed the robots to be controlled with small magnetic fields...
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Pancreatic cancer: Some blood pressure drugs put women at risk
New research suggests that certain blood pressure drugs may increase the risk of pancreatic cancer in postmenopausal women. pancreatic cancer, a new study suggests. Zhensheng Wang, a postdoctoral researcher at the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine in Houston, TX, along with his colleagues, set out to examine the effects...
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Do feminine hygiene products actually lead to a higher risk of infection?
The ladies’ personal care aisle in any drugstore is bound to offer a wide array of intimate hygiene products — from gentle washes to wet wipes for your on-the-go needs. We use these products on a regular basis, but are they likely to cause harm? A recent study finds a worrying correlation between the use...
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Reviewing the association between skin diseases and metabolic syndrome
Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high-risk patients Background There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS [1] comprises a combination of parameters that predispose individuals to the development of...
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How bone marrow niches keep stem cells thriving
CAR cells are specialized mesenchymal stem cells, which express the specific transcription factors, Ebf1/3, inhibiting osteoblast differentiation to remain undifferentiated, maintain marrow cavities, enhance CXCL12 and SCF expression, and create HSC niches. Hematopoietic stem cells (HSCs) are a class of stem cells located in bone marrow. HSCs give rise to every type of blood cell—from...
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Neuroscientists use magnetic stimulation to amplify PTSD therapy
Dr. Michael Motes (left) and Dr. John Hart Jr., along with other researchers at UT Dallas, discovered that repetitive transcranial magnetic stimulation boosted the effectiveness of cognitive processing therapy for post-traumatic stress disorder. Researchers from The University of Texas at Dallas have found that a standard therapy for post-traumatic stress disorder (PTSD) is more effective...