Dublin, Ireland: Patients with rare, but incurable cancers of the digestive tract have responded well to a combination of two drugs that block the MEK and BRAF pathways, which drive the disease in some cases. They have survived for longer without the disease progressing than the usual average time of less than five months, even...
Post
New promising compound against heart rhythm disorders and clogged arteries
The pharmacological agent outperforms current drugs in most of the cases, show multiple experiments PENSOFT PUBLISHERS A new pharmacological agent demonstrates promising results for the prevention of a wide range of heart rhythm disorders, including both cardiac and brain injury-induced arrhythmias. Furthermore, the compound (SS-68) demonstrates significant activity in conditions of reduced blood flow to...
Post
Enzymes in the cross-hairs
New strategies in the battle against antibiotic resistance TECHNICAL UNIVERSITY OF MUNICH (TUM) More and more bacteria are resistant to available antibiotics. A team of chemists from the Technical University of Munich (TUM) now presents a new approach: they have identified important enzymes in the metabolism of staphylococci. Blocking these enzymes in a targeted manner...
Post
Stroke: Preventing the damage by acting on the neuronal environment?
To protect neurons and limit the damage after a stroke, researchers from the CNRS, the University of Caen-Normandie, University Paris-Est Créteil, and the company OTR3 have pursued an innovative path: targeting the matrix that surrounds and supports brain cells. Their results, just published in the journal Theranostics, have confirmed this strategy on rats and will...
Post
Nightingale’s technology links chronic inflammation with disease risk and shorter lifespan
Investigating a new marker for chronic inflammation GlycA, researchers have linked GlycA to increased risk for shorter lifespan and several organ-related diseases; the findings were made using Nightingale Health’s blood testing technology NIGHTINGALE HEALTH Chronic inflammation is currently a hot topic in health and wellness, being linked to everything from heart disease to clinical depression. In an...
Post
New marker provides insights into the development of type 2 diabetes
DEUTSCHES ZENTRUM FUER DIABETESFORSCHUNG DZD Small chemical changes in the DNA building blocks, which may be influenceable by lifestyle factors, can reduce the amount of IGFBP2. A DIfE / DZD research team has now reported in the journal Diabetes that these epigenetic changes increase the risk of type 2 diabetes. Moreover, people with high blood levels of the binding...
Post
Multiple sclerosis: Accumulation of B cells triggers nervous system damage
TECHNICAL UNIVERSITY OF MUNICH (TUM) B cells are important in helping the immune system fight pathogens. However, in the case of the neurological autoimmune disease Multiple Sclerosis (MS) they can damage nerve tissue. When particular control cells are missing, too many B cells accumulate in the meninges, resulting in inflammation of the central nervous system....
Post
Link between autoimmune, heart disease explained in mice
Immune cells cause cholesterol to be trapped in blood vessels WASHINGTON UNIVERSITY SCHOOL OF MEDICINE People with autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis are at high risk of developing cardiovascular disease, even though none of these conditions seem to target the cardiovascular system directly. Now, researchers at Washington University School of Medicine...
Post
Neurons that fire together, don’t always wire together
As the adage goes “neurons that fire together, wire together,” but a new paper published today in Neuron demonstrates that, in addition to response similarity, projection target also constrains local connectivity. IMAGE: PRIMARY VISUAL CORTEX NEURONS PROJECTING TO HIGHER VISUAL AREA AL. CREDIT: SAINSBURY WELLCOME CENTRE Researchers from the Sainsbury Wellcome Centre have been looking to elucidate...
Post
Investigational urate elevation does not appear to raise hypertension risk
Both phase 2 clinical trial results and animal model studies find no association between urate manipulation and blood pressure MASSACHUSETTS GENERAL HOSPITAL A study from a group of Massachusetts General Hospital (MGH) investigators may reduce the concern that elevated levels of urate, an approach being investigated to treat several neurodegenerative disorders, could increase the risk...