Susan Jeffrey March 26, 2019 The US Food and Drug Administration (FDA) has approved siponimod(Mayzent, Novartis) to treat adults with relapsing forms of multiple sclerosis(MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive (SP) disease, the agency announced. “Multiple sclerosis can have a profound impact on a person’s life,” Billy Dunn, MD, director of the...
Post
Common lung conditions linked to heart disease
Patients with some of the most common lung diseases are substantially more likely to suffer a heart attack and develop other major heart problems according to new research. The team of heart and lung doctors from the University of Manchester and Aston Medical School found people with asthma, chronic obstructive pulmonary disease (COPD) and lung fibrosis, were more likely to develop, and die from, heart disease and heart failure. The study of nearly 100,000 people with lung disease in...
Post
Unresolved injury, not fibrosis, contributes to cisplatin-induced CKD
by Julie Parry, Yale University Yale School of Medicine researchers have found that the progression of acute kidney injury to chronic kidney disease (CKD) caused by use of the chemotherapy drug cisplatin is due to unresolved injury and sustained activation of regulated necrosis pathways rather than fibrosis. The new study is highlighted on the cover of...
Post
Consider non-surgical brain stimulation for severe depression, say experts
by British Medical Journal Non-surgical brain stimulation should be considered as alternative or add-on treatments for adults with severe forms of depression, suggests a study published by The BMJ today. The findings also suggest that more established techniques should take priority over new treatments with a more limited evidence base. Depression is a common and debilitating illness that is usually treated with drugs and psychological therapies....
Post
Fewer reproductive years in women linked to an increased risk of dementia
by American Academy of Neurology Women who start their period later, go through menopause earlier or have a hysterectomy may have a greater risk of developing dementia, according to a new study published in the March 27, 2019, online issue of Neurology, the medical journal of the American Academy of Neurology. The study found a link between increased risk of dementia...
Post
Like racecars and geese, cancer cells draft their way to new tumor sites
NASCAR has nothing on cancer cells when it comes to exploiting the power of drafting, letting someone else do the hard work of moving forward while you coast behind. Building on the relatively new discovery that metastatic cancer cells leave tumors and travel in clusters, not singles, a Vanderbilt University team of biomedical engineers learned the process...
Post
Females respond poorly to ketogenic weight loss diet in an animal model
by The Endocrine Society The ketogenic diet recently has been touted for weight loss and improving blood sugar control, but a new study finds that females fail to show these metabolic benefits on this high-fat, very low-carbohydrate diet. Results of the animal study will be presented Sunday at the Endocrine Society’s annual meeting in New Orleans,...
Post
Autoimmune diseases are related to each other, some more than others
by The Endocrine Society Researchers using the world’s largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. “These results...
Post
Neutrons paint atomic portrait of prototypical cell signaling enzyme
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis. The discovery was made by an international team of researchers using macromolecular neutron crystallography at the Department of...
Post
Time-restricted eating may prove to be a dietary intervention against breast cancer
Reviewed by Alina Shrourou, BSc Changing when you eat rather than what you eat may prove to be a dietary intervention against breast cancer, suggests a new mouse study to be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. A growing body of evidence indicates that obesity and metabolic syndrome–a...