Scientists have found that a technique for targeting a specific group of brain cells associated with Parkinson’s disease is also effective at treating a separate group of brain cells. Researchers may have found a new two-pronged treatment approach to Parkinson’s disease. These findings now appear in the journal Neurotherapeutics. The initial technique is a type...
Researchers find that regulating lipid metabolism in neurons helps axon regeneration
by Hong Kong University of Science and Technology Typical examples include paralysis due to a spinal cord injury and visual field atrophy, or even complete blindness due to optic nerve atrophy in glaucoma patients. Therefore, in-depth study of the basic biological processes that affect axon regeneration is particularly important for human health. Traditional research on...
Precancerous milestone discoveries improve clinical risk prediction and cancer prevention
by Bob Yirka , Medical Xpress A team of researchers affiliated with multiple institutions in Massachusetts has discovered some of the precancerous milestones that can lead to breast cancer in women with a BRCA2 gene mutation. In their paper published in the journal Science Advances, the group describes their detailed analysis of breast tissue taken...
New therapy may ease congestion for heart failure patients
by Elisabeth Reitman, Yale University The American Heart Association estimates that the total cost of heart failure in the United States could reach $70 billion by 2030. Volume overload contributes to 90% of heart failure-related hospitalizations in the U.S. A new therapy developed by Sequana Medical demonstrates that direct sodium removal (DSR) is a safer...
Movement study could be significant in helping understand brain rehabilitation
by Alan Williams, University of Plymouth The human brain’s ability to recall a single movement is significantly affected by the characteristics of previous actions it was learned with, a new study has shown. Research led by the University of Plymouth explored how distinct prior actions affected a person’s ability to perform certain simple movements, corresponding...
Researchers discover new piece of the puzzle for Parkinson’s disease
by KU Leuven Biomedical scientists at KU Leuven have discovered that a defect in the ATP13A2 gene causes cell death by disrupting the cellular transport of polyamines. When this happens in the part of the brain that controls body movement, it can lead to Parkinson’s disease. Parkinson’s disease is one of the most common neurodegenerative...
Sugar-derived molecules kill viruses in groundbreaking new treatment
By Michael Irving Viruses are surprisingly difficult to kill – most of the drugs and chemicals that do the job are also harmful to human health. But now, scientists have developed a new virucidal substance derived from sugar, making it deadly to a wide range of viruses but safe for us. The vast majority of...
Poliovirus therapy shows potential as cancer vaccine in lab studies
by Duke University Medical Center A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as part of a cancer vaccine. In preclinical studies using mice and human cancer cells, an injection of the...
Not ‘Brains in a Dish’: Cerebral Organoids Flunk Comparison to Developing Nervous System
Widely Used Brain Organoids are ‘Confused’ and ‘Disorganized’ Compared to New Atlas of the Developing Human Brain. Brain organoids – 3-D balls of brain-like tissue grown in the lab, often from human stem cells – have been touted for their potential to let scientists study the formation of the brain’s complex circuitry in controlled laboratory...
Cheap nanoparticles stimulate immune response to cancer in the lab
University of Wisconsin–Madison researchers have developed nanoparticles that, in the lab, can activate immune responses to cancer cells. If they are shown to work as well in the body as they do in the lab, the nanoparticles might provide an effective and more affordable way to fight cancer. They are cheaper to produce and easier...