By Dr. Tomislav Meštrović, MD, Ph.D.Apr 15 2020 Genetic variation analysis and the evidence of recombination events point towards the conclusion that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might have circulated cryptically among humans for years, as reported by a recent paper on a preprint server bioRxiv. The pandemic of coronavirus disease (COVID-19) caused...
By Rich Haridy A new study, funded by the National Institutes of Health’s National Institute on Aging, is offering novel insights into how protein expressions can be altered during the course of Alzheimer’s disease. The research suggests proteins regulating glucose metabolism and the anti-inflammatory activity of brain immune cells are linked with Alzheimer’s pathology, and...
by Linda Nilsson, Karolinska Institutet Researchers from Karolinska Institutet in collaboration with a lab in San Antonio U.S., have uncovered how a specific population of lymphocytes promotes autoimmune disease by giving up their regulatory role in the immune system. The newly discovered mechanism is published in PNAS from research led by Dr. Saikiran Sedimbi and...
by Bob Yirka , Medical Xpress A team of researchers affiliated with multiple institutions in the U.S. and the U.K. has found that a single error during cell division can trigger a cascade of mutational events, generating many of the features found in cancer genomes. In their paper published in the journal Science, the group...
by Paul Mayne, University of Western Ontario Consistent signs of compromised inhibition found in a study of concussion sufferers were mirrored in separate tests on Canadian university football players. These findings open new doors to predicting the impact of the often debilitating injury, as well as raise questions about the long-term impact of contact sports,...
by Ana María Rodríguez, Ph.D., Baylor College of Medicine When a patient with puzzling neurological symptoms enrolled in the Undiagnosed Diseases Network, researchers led by Dr. Hugo J. Bellen were set on solving the mystery. The patient presented with an unidentified late-onset neurodegenerative disorder. The team named this new syndrome “Mitchell disease” in reference to...
by Skolkovo Institute of Science and Technology In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer. Using a siRNA approach, a field in which Dr. Zatsepin (Skoltech) excels, coupled with lipid nanoparticle technology developed in the Anderson laboratory (MIT), the scientists...
Early preclinical tests in lab models are encouraging CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI – Infectious disease scientists report early development of a potential universal vaccine for Ebola viruses that preclinical tests show might neutralize all four species of these deadly viruses infecting people in recent outbreaks, mainly in Africa. Scientists at Cincinnati Children’s Hospital...
AMERICAN ASSOCIATION FOR CANCER RESEARCH Bottom Line: Patients experienced a greater occurrence of infections in the years preceding a cancer diagnosis. Journal in Which the Study was Published: Cancer Immunology Research, a journal of the American Association for Cancer Research Author: Shinako Inaida, PhD, a visiting researcher at the Graduate School of Medicine at Kyoto...
KUMAMOTO UNIVERSITY A Japanese research team has developed a cyclic peptide (a chain of amino acids bonded circularly) that enhances blood-brain barrier (BBB) penetration. By attaching the cyclic peptide to the surface of nanoparticles, research and development of new drug nanocarriers for drug delivery to the brain becomes possible. Unlike blood circulation to the peripheral...
