Researchers at Washington University School of Medicine in St. Louis have developed an approach to estimating when a person who is likely to develop Alzheimer’s disease but has no cognitive symptoms, will start showing signs of Alzheimer’s dementia. The algorithm, available online in the journal Neurology, uses data from a kind of brain scan known...
by Elsevier rsEEG results, DCM model structure, and rsEEG simulations. A – The mean normalized eyes closed and eyes open rsEEG power spectra (±s.e.m.) across all channels for Con (n=98; blue) and PScz (n=95; red) groups, divided into four frequency bands (dotted lines): θ (3-7 Hz), α (8-14 Hz), β (15-30 Hz) and γ (>31...
by IOS Press Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson’s disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson’s Disease, “Repairing the Parkinsonian Brain,” experts...
by University College London Truncating variants in ALPK3 are a cause of 1–2% of autosomal dominant hypertrophic cardiomyopathy and are associated with a phenotype characterized by extensive fibrosis and a predominantly concentric or apical pattern of left ventricular hypertrophy without left ventricular outflow tract obstruction. (A) Main phenotype characteristics and outcomes. ALPK3tv, alpha-protein kinase 3-truncating variants;...
by Amy Norton Certain changes in a part of the brain stem, visible in scans, might be a potential early indicator of Alzheimer’s disease, a new study suggests. Using different brain imaging techniques, researchers found that lesser “integrity” in the brain stem region was linked to a faster decline in memory and thinking in older adults, as well as certain...
by Weill Cornell Medical College Credit: Blausen Medical, CC BY-SA 4.0 The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain...
by UT Southwestern Medical Center Activation of T cell immune response with the interaction of MHC-II (red) with the T cell receptor (TCR, blue), and also CD4 (light blue). CD4 and MHC-II are proteins expressed by T cells and antigen-presenting cells, respectively, to aid the recognition of antigens by TCRs. Credit: UT Southwestern Medical Center....
High levels of a polyubiquinated form of phosphatase and tensin homolog (PTEN) were associated with an almost four-fold higher risk of a 40% decline in kidney function in a cohort of American Indians with or at high risk of diabetic kidney disease. A recently identified modified form of the protein PTEN has been implicated in...
MINNEAPOLIS – Adults and children with migraines may get less quality, REM sleep time than people who don’t have migraines. That’s according to a meta-analysis published in the September 22, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. Children with migraines were also found to get less total sleep time than their healthy...
September 23, 2021 –Corticosteroid injections are a common treatment option for pain and inflammation in patients with osteoarthritis of the hip. But a new study adds to concerns that hip steroid injections may lead to increased rates of a serious complication called rapidly destructive hip disease (RDHD), according to a paper in The Journal of Bone & Joint Surgery. The...
