Share on Pinterest A newly developed algorithm may detect early signs of Alzheimer’s. Westend61/Getty Images Written by Robby Berman on September 20, 2021 — Fact checked by Anna Guildford, Ph.D. Mild cognitive impairment (MCI) often precedes the development of Alzheimer’s disease. Functional MRI (fMRI) scans can capture subtle signs of MCI, but they are difficult...
Senescent cells accumulate with age, but are never more than a tiny fraction of somatic cells in most tissues, even in very late life. Senescent cells nonetheless cause considerable harm via the signals that they produce, the senescence-associated secretory phenotype (SASP). These signals provoke chronic inflammation, harmful remodeling of tissue, and dysfunctional activity in nearby cells. That comparatively few senescent cells...
A study published in the journal Cell Host & Microbe reported that the increased presence of certain bacteria in a gut biome indicates a greater likelihood that colon polyps will become cancerous. In his research, William DePaolo, associate professor at the University of Washington School of Medicine, tracked 40 patients who had undergone routine colonoscopies and had biopsies taken near the polyps to identify bacteria...
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an...
DALLAS, Sept. 20, 2021 — More than 40% of adults ages 50 to 64 years in Sweden without known heart disease were found to have some degree of atherosclerosis, according to a new study published today in the American Heart Association’s flagship journal Circulation. Atherosclerosis, or the buildup of fatty deposits in blood vessels that supply blood...
A large international collaboration led by researchers from the Johns Hopkins Kimmel Cancer Center has identified promising new targets for pancreatic cancer treatment and early diagnosis after examining various aspects of these tumors’ genes and proteins. Their findings, published online Sept. 16 in Cell, could offer hope to patients with this deadly disease. “Right now, patients with pancreatic cancer have...
by Walter and Eliza Hall Institute WEHI researcher Dr Michael Chopin have made a surprise discovery about how immune ‘sentinel’ cells are maintained, which could have implications for drugs in development for treating cancer. Credit: WEHI WEHI researchers have made a surprise discovery about how immune ‘sentinel’ cells are maintained, which could have implications for drugs in development...
by Centenary Institute Figure 1. Erianin suppresses colony formation but not migration in both LNCaP and PC3 cells. (A, B) Cells were treated with erianin at indicated concentrations for 10 days. Images are representative of three independent experiments (A) and the number of colonies was quantified (B). (C, D) Wound healing assay was performed to assess cell...
by European Society for Medical Oncology High grade dysplasia (carcinoma in situ) in the uterine cervix. The abnormal epithelium is extending into a mucus gland to the left of centre. This disease can progress to invasive cancer (squamous cell carcinoma) of the cervix. Credit: Haymanj/public domain The addition of immunotherapy to standard first-line treatment extends survival...
by University of Bonn Graphical abstract. Credit: DOI: 10.1016/j.patter.2021.100351 The presence of cancer of the lymphatic system is often determined by analyzing samples from the blood or bone marrow. A team led by Prof. Dr. Peter Krawitz from the University of Bonn had already shown in 2020 that artificial intelligence can help with the diagnosis of...
