by Doug Donovan, Johns Hopkins University Demographic data from the Johns Hopkins Coronavirus Resource Center helps users visualize the tragic consequences of COVID-19 in the U.S. by age, race and ethnicity, and gender and sex. Credit: Johns Hopkins University The Johns Hopkins Coronavirus Resource Center today released demographic data and new tools to show the impact...
Differences in cellular signaling offer clues to insulin resistance
by Max Bingham, Harvard Medical School Credit: Pixabay/CC0 Public Domain In what could be a starting point for new therapeutics to tackle insulin resistance, a major driver of type 2 diabetes and metabolic syndrome present in 20–30 percent of the general U.S. population, researchers recently found that insulin resistance in the general population seems likely to be caused...
How protein clogs in cellular entrances cause Parkinson’s disease
by University of Connecticut Credit: Yulan Xiong Mutations in a protein known to cause Parkinson’s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in the 27 July issue of Science Signaling. The toxic traffic jams that result eventually lead to certain brain cell death and the characteristic symptoms of Parkinson’s. “We...
Further evidence that vitamin D might protect against severe COVID-19 disease and death
by Trinity College Dublin A scatter plot of Mendelian Randomisation analyses of 134 vitamin D SNPs on COVID-19 risk. Credit: DOI: 10.1038/s41598-021-97679-5 New research from Trinity College and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin)...
Moderna Developing Single-Dose Booster Shot for COVID-19 and Flu
(Reuters) – Moderna Inc said on Thursday it is developing a single vaccine that combines a booster dose against COVID-19 with its experimental flu shot. The company hopes to eventually add vaccines it is working on for respiratory syncytial virus (RSV) and other respiratory diseases as an annual shot. “We believe this is a very...
LSD-triggered altered behaviors linked to abnormal brain communication
by Baylor College of Medicine Credit: CC0 Public Domain Lysergic acid diethylamide, or LSD, is a potent hallucinogen that alters the perception of reality. Researchers at Baylor College of Medicine have discovered changes in the brain, triggered by the drug, that may explain the profound altered behavior associated with LSD, helping to understand how the brain generates behavior....
Evidence for a neuroprotective effect from transcription factor BCL11A
by University of Bonn Neurons producing the transcription factor BCL11A appear in green. Credit: Marianna Tolve The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the substantia nigra—a particularly sensitive part of the brain—is what causes...
Researcher unlocks new approach for possible pancreatic cancer treatment
by Indiana University Credit: Unsplash/CC0 Public Domain Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how restoring a missing molecule in pancreatic fibrosis could help deliver treatments to cancer cells. Pancreatic cancer is one of the deadliest cancers with only 10.8 percent of people surviving five years after diagnosis. One risk factor for...
Researchers reveal a possible new pathway for treating epileptic seizures in patients with autism
by Purdue University Credit: Pixabay/CC0 Public Domain Autism affects about 2% of children in the United States, and about 30% of these children have seizures. Recent large-scale genetic studies have revealed that genetic variants in a sodium channel, called voltage-gated sodium channel Nav1.2, are a leading cause of autism. Overactive sodium channels in the neuron cause...
One protein to rule them all: A central target for treating dementia
by Tokyo Medical and Dental University Supercomputer-based dynamic molecular network analysis predicted HMGB1-TLR4 induced signal as the most important target of two major neurodegenerative dementias. The prediction was verified by significant phenotypic and pathological improvements of four types of mouse model of frontotemporal lobar degeneration treated by anti-HMGB1 antibody. Credit: Department of Neuropathology, TMDU Dementia...