by Texas Heart Institute Wls knock-down by CRISPR/Cas9 in cardiomyocytes promotes cardiac fibroblast proliferation during neonatal heart regeneration. Green indicates Vimentin-positive cardiac fibroblasts; red indicates proliferating cells with EdU labeling; blue indicates nuclei by DAPI staining. Credit: Texas Heart Institute The Texas Heart Institute has announced that a new study from its prolific Cardiomyocyte Renewal...
by Rockefeller University Electron micrograph of a negatively stained human papilloma virus (HPV) which occurs in human warts. Credit: public domain Most people get infected with human papilloma virus at some point in their lives but, thanks to a robust immune response, are none the wiser. Unless giant horn-like growths sprout from their skin. An exceedingly...
by Cory Nealon, University at Buffalo The illustration shows a senescent muscle cell (left), including the numerous factors that led to its declining ability to divide and grow. It also shows the same type of cell after the overexpression of NANOG, which reversed many of the factors. Credit: University at Buffalo A University at Buffalo-led research team has...
by Public Library of Science Hippocampal dentate gyrus in HSHA mice, showing significant astrocyte activation (GFAP: white) and oxidative stress (8OHdG: green) surrounding the cerebral capillaries (laminin-a4: magenta). Nuclei staining with DAPI (blue). Credit: John Charles Louis Mamo, Lam V et al., 2021, PLOS Biology, CC BY 4.0 (creativecommons.org/licenses/by/4.0/) Amyloid protein made in the liver can cause...
by University of California – San Diego Credit: Pixabay/CC0 Public Domain Using a virus that grows in black-eyed pea plants, nanoengineers at the University of California San Diego developed a new treatment that could keep metastatic cancers at bay from the lungs. The treatment not only slowed tumor growth in the lungs of mice with either...
Such treatments are extraordinarily promising and costly. Will the Biden administration commit to spending that could speed clinical trial results? Helen Obando, at home in Mesa, Ariz. An experimental gene therapy she received last year successfully rid her of her sickle cell disease, eliminating her intense suffering and transforming her into a teenager like any...
A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1. In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS),...
It is thought that an appreciable fraction of the chronic inflammation of aging is caused by changes in the gut microbiome. There is a bidirectional interaction between the immune system and the microbial populations of the intestinal tract. The immune system gardens these populations, destroying problematic microbes. Microbes secrete metabolites and other molecules that can either benefit or harm the function of the immune system,...
Meningioma is a type of a benign brain tumour, originating in meninges surrounding the brain. In older patients meningiomas are usually not operated, because surgeries might be painful and potentially dangerous for older people. However, a new study from the University of Helsinki revealed that meningioma can increase life expectancy and improve the quality of...
CRITICAL PATH INSTITUTE (C-PATH) TUCSON, Ariz. and ALISO VIEJO, Calif., September 14, 2021 — Critical Path Institute (C-Path), who’s aim is to catalyze the development of new approaches that advance medical innovation and regulatory science, today announced a collaboration with RARE-X to improve ways researchers can access and analyze patient data. RARE-X is a nonprofit organization dedicated...
