by Foundation for Research and Technology – Hellas Graphical abstract. Credit: Foundation for Research and Technology – Hellas International scientific collaboration between Researchers at the Institute of Molecular Biology & Biotechnology of FORTH, and Scientists at the National and Kapodistrian University of Athens and the University of Oslo, in Norway, has uncovered the novel role of the DNA base excision...
ST. JUDE CHILDREN’S RESEARCH HOSPITAL IMAGE: CHUNLIANG LI, PH.D., ST. JUDE DEPARTMENT OF TUMOR CELL BIOLOGY CREDIT: ST. JUDE CHILDREN’S RESEARCH HOSPITAL CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children’s Research Hospital have found direct evidence that CTCF governs chromatin accessibility, the process of opening...
UNIVERSITY OF CHICAGO MEDICAL CENTER A study led by researchers at the University of Chicago and Indiana University has determined that a protein called elF5A is necessary for driving inflammation in macrophage cells in obesity. Blocking DHPS, the enzyme that modifies and activates elF5A, led to reduced inflammation and improved glucose control in mice. The study was...
by Princess Máxima Center for Pediatric Oncology A double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0 Stem cell transplants do not lead to changes in the DNA of the donor cells. That’s according to a new study, which provides important evidence for the safety of this procedure. The researchers also found clues that an anti-virus drug...
by Yale University Immunofluorescent staining of chronic UV exposed mouse skin showing clonally expanding mutant skin cells (keratinocytes, red) and immune cells (Langerhans cells, green, and T cells, blue). Credit: Yale University Yale researchers have identified a cellular spy that tricks certain immune cells into helping potentially deadly skin cancer to reproduce. The discovery, reported in the journal Proceedings...
UNIVERSITY OF CALIFORNIA – SAN DIEGO Nanoengineers at the University of California San Diego have developed COVID-19 vaccine candidates that can take the heat. Their key ingredients? Viruses from plants or bacteria. The new fridge-free COVID-19 vaccines are still in the early stage of development. In mice, the vaccine candidates triggered high production of neutralizing...
RADIOLOGICAL SOCIETY OF NORTH AMERICA OAK BROOK, Ill. – Compared with commonly used clinical risk factors, a sophisticated type of artificial intelligence (AI) called deep learning does a better job distinguishing between the mammograms of women who will later develop breast cancer and those who will not, according to a new study in the journal Radiology. Researchers said...
by University College London Section of graphical abstract from paper. Credit: Med UCL researchers have shown that damage to the lining of the gut plays an important role in the development of rheumatoid arthritis, paving the way for a new approach to treating the disease. In the pre-clinical study, which used mouse models and patient samples, the research team propose...
by University of Helsinki Fig. 1: Generating proliferative induced hepatocytes using defined transcription factors and oncogenic drivers. A Schematic outline of the cell transformation assay for making lineage-specific cancer by lentiviral expression of three lineage-specific TFs to convert HFs to induced hepatocytes (iHep) and defined oncogenic drivers to transform iHeps to proliferating and tumorigenic cells. B...
by The Physiological Society Credit: Unsplash/CC0 Public Domain When rats are fed a high fat diet, this disturbs the body clock in their brain that normally controls satiety, leading to over-eating and obesity. That’s according to new research published in The Journal of Physiology. The number of people with obesity has nearly tripled worldwide since 1975. In England...
