Robert F. Service The artificial intelligence (AI) revolution in protein structure prediction continues. Only 1 year ago, software programs first succeeded in modeling the 3D shapes of individual proteins as accurately as decades-old experimental techniques can determine them. This summer, researchers used those AI programs to assemble a near-complete catalog of human protein structures. Now,...
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Danielle Ellis, B.Sc. Serum samples obtained from the recipients of the BriLife® coronavirus disease 2019 (COVID-19) vaccine candidate have shown high potency in neutralizing the alpha, beta, gamma, and delta variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Neutralization of SARS-CoV-2 variants by rVSV-ΔG-spike-elicited human sera. Image Credit:...
Sensitive teeth are bothering millions of people in the world. And while it seems like a small casual problem it can really impact one’s quality of life. Now scientists at the University of Queensland have found a way to manage tooth sensitivity by taking advantage of nanotechnology. If biting ice cream sounds terrifying to you,...
A molecule known as anaplastic lymphoma kinase (ALK) is a driver of several cancers, including pediatric neuroblastoma, B-cell lymphomas, and myofibroblast tumors. But for years much about this molecule — its role in the body, which molecules interact with it, what it looks like — has remained unknown, limiting efforts to target it for treatment....
(HealthDay)—Six inflammatory proteins are upregulated in plasma several years before diagnosis of ulcerative colitis, according to a report published in the November issue of Gastroenterology. Daniel Bergemalm, M.D., Ph.D., from the Örebro University Hospital in Sweden, and colleagues characterized preclinical systemic inflammation in ulcerative colitis in plasma samples biobanked from 72 individuals who developed ulcerative colitis later in...
HOUSTON ― Results from a Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center showed that treatment with belzutifan, a small-molecule inhibitor of hypoxia-inducible factor (HIF)-2a, achieved strong clinical activity in patients with renal cell carcinomas (RCC) and non-renal cell carcinoma neoplasms associated with von Hippel-Lindau (VHL) disease. The study was published...
by University of Michigan In this representation, the red background is the cytosol, and ribosomes are in light green. tRNAs are the purplish blue blobs. Some tRNAs are in the cytosol and others are bound to the green ribosomes. The mRNAs are represented in yellow. The thin purple strand coming out the other side of the...
by Dana-Farber Cancer Institute Credit: Pixabay/CC0 Public Domain A combination of two targeted cancer drugs showed unprecedented, “clinically meaningful” activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute. The drug combination, which blocked an overactive cell-growth signaling pathway, shrank...
by Nadine A Yehya, UC Davis Creative rendition of SARS-CoV-2 particles (not to scale). Credit: National Institute of Allergy and Infectious Diseases, NIH With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field. Researchers are working to find effective vaccines and therapies,...
Credit: Pixabay/CC0 Public Domain Scientists in South Africa said Thursday they had detected a new COVID-19 variant with a large number of mutations, blaming it for a surge in infection numbers. The number of daily infections in Africa’s hardest-hit country has increased tenfold since the start of the month. “Unfortunately we have detected a new...
