by La Trobe University Output from amyloid assembly prediction software for SARS-CoV-2 ORF6 and ORF10 sequences. a, b Outputs from amyloid predicting algorithm ZIPPER identifying hexapeptide fragments predicted to form steric zippers nucleating the assembly of amyloid fibrils. Hexapeptides with Rosetta energies below −23 kcal mol−1 are predicted to be highly amyloidogenic and are shown with...
by Noor Adatia Credit: Unsplash/CC0 Public Domain A spike in flu cases across the country, along with another COVID-19 surge, is leaving more people vulnerable to catching some form of disease—especially those who aren’t vaccinated. And although the flu is most common during the fall and winter, people remain susceptible to influenza year round, including...
by Monash University Credit: CC0 Public Domain The world’s first study of the impact of childhood fitness and obesity on cognition in middle age, followed over 1200 people who were children in 1985 for over 30 years, has found that better performance on physical tests is related to better cognition later in life and may...
BY AMY CAMPBELL, MS, RD, LDN, CDCES | JUNE 7, If you’ve watched television lately, you might have seen ads for supplements and diet plans claiming to reverse insulin resistance and help you lose weight. The term “insulin resistance” has been trending in the media for a while now, and it might be hard to figure out what...
By Akila Muthukumar June 15, 2022 ADOBE Anew study finds that a popular erectile dysfunction drug, which is increasingly being used to try to prevent heart complications in people with type 2 diabetes, doesn’t benefit women with diabetes. Only one previous randomized study examining the heart benefits of erectile dysfunction drug for patients with diabetes enrolled...
Written by Alex Brewer, PharmD, MBA | Reviewed by Amy B. Gragnolati, PharmD, BCPS Published on January 5, 2022 Key takeaways: A weakened immune system can make it harder to fight infections. Some medications can weaken your immune system. These are generally called immunosuppressants, and they can treat many health conditions. Most vaccines are safe...
Atogepant appears to be effective and well tolerated for the preventive treatment of migraine, according to a study published online June 8 in JAMA Network Open. Richard B. Lipton, M.D., from Albert Einstein College of Medicine and the Montefiore Headache Center in New York City, and colleagues evaluated the efficacy and safety of atogepant for the preventive treatment...
Diastolic blood pressure and grip strength appear to be consistently lower in aging individuals with type 1 diabetes (T1D), according to a study published online May 26 in the Canadian Journal of Diabetes. Lauren V. Turner, from York University in Toronto, and colleagues used data from the Canadian Longitudinal Study on Aging to assess whether aging individuals with T1D have...
by Mônica Tarantino, FAPESP Research reveals the mechanisms whereby methionine-deficient and methionine-supplemented diets can alter gene expression and damage liver cells. Credit: DBCLS and Ben Mills/Wikimedia Commons Having shown that diet can influence gene expression, science is starting to find out more about how this happens. According to an article recently published in Food and Chemical Toxicology, a...
Precision medicine has been a buzzword across the medical field for over a decade. But what does it mean for cancer care, and how is it influencing new therapies for patients? Initially, precision cancer medicine focused on targeting specific mutated genes. We thought that understanding the genetic mutations of a tumor would help us develop targeted drugs...
