by The Endocrine Society Credit: CC0 Public Domain A new study finds overweight and obese people maintained an average weight loss of 10.6% over 3 to 5 years with a program of lifestyle changes in combination with anti-obesity medications. Weight loss of more than 10% provides significant health benefits, according to researchers who are presenting...
Researchers find that aspirin alters colorectal cancer evolution
by University of California, Irvine A schematic illustrating the mathematical model. The six cell types are denoted by circles, the mutation rates that give rise to different types are marked by the straight arrows. Type 6 (late adenoma) is marked in red. Crypt conversion rates are indicated by circular arrows and crypt fission by multiple...
Healthy human brains are hotter than previously thought, exceeding 40 degrees C
by UK Research and Innovation Healthy human brain temperature extremes showing relatively hot temperatures in post-ovulation females in the morning compared with coldest temperatures in males at night. Lighter yellow represents hotter temperatures. Credit: N Rzechorzek/MRC LMB/Brain New research has shown that normal human brain temperature varies much more than we thought, and this could...
Jerusalem Post Science Spanish-Israeli team finds mechanism to make blood cancer cells harmless
By JUDY SIEGEL-ITZKOVICH Published: JUNE 12, 2022 17:53Updated: JUNE 12, 2022 19:35 3D Medical Animation still showing an increase in white blood cells of a person suffering from Leukemia.(photo credit: WIKIMEDIA COMMONS/MANU SHARMA/WWW.SCIENTIFICANIMATIONS.COM) Leukemia is a group of blood cancers that usually begin in the bone marrow due to a lack of normal blood cells and create...
Researchers develop pancreatic beta-cell restoring therapy for treating type 1 diabetes
by The Endocrine Society A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and...
An anti-cancer drug acts as an epigenetic memory aid, scientists find
by Hillary Sanctuary, Ecole Polytechnique Federale de Lausanne HDACi treatment enhances contextual fear memory formation and hippocampal, but not striatal LTP, despite reducing HDAC activity in both brain regions. (A) Schematic of the experimental outline. (B) HDACi combined with CFC increases the percent of time spent freezing (>1 s) during 3-min reexposure to the conditioning chamber...
Activation of microglia in the spinal cord after nerve injury found to contribute to pain hypersensitivity
by Bob Yirka , Medical Xpress A perineuronal net surrounding a projection neuron in the spinal cord and depicts microglia digesting the net. Degradation of the perineuronal net by microglia causes increased neuronal activity and pain. Credit: Designs that Cell A team of researchers working at McGill University has found that activation of microglia in...
The first detailed characterization of candelabrum cells in the cerebellar cortex
by Ingrid Fadelli , Medical Xpress Before the team’s paper, the distribution and numbers of candelabrum cells were unknown. The researchers showed that candelabrum cells are abundant and present in all regions of the cerebellar cortex, arguing for an important role in cerebellar processing. This image shows mRNA signal from candelabrum cells using single molecule...
Immunity boosting treatment enhances CAR-T cell therapy for blood cancers
by Julia Evangelou Strait, Washington University School of Medicine A study by researchers at Washington University School of Medicine in St. Louis shows that treatment with an immunity boosting protein called interleukin 7 (IL-7) after an infusion of genetically modified T cells causes the cancer-fighting CAR-T cells to grow in number and become more effective at...
People who consume too much high fructose corn syrup could be at risk for NAFLD
by The Endocrine Society Credit: Unsplash/CC0 Public Domain High fructose consumption should be avoided to prevent the development of non-alcoholic fatty liver disease (NAFLD), according to research being presented Sunday, June 12 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga. Fructose is a natural sugar present in fruits, fruit juices, certain vegetables...