JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IMAGE: FIRST AUTHOR, ALBERTO BUENO-COSTA AND CHIEF SUPERVISOR, DR. MANEL ESTELLER CREDIT: JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE Barcelona, June 9th, 2022. A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of...
Little evidence testosterone treatment increases the risk of cardiovascular events, most in-depth analysis suggests
by Lancet Credit: Unsplash/CC0 Public Domain Testosterone replacement therapy appears safe in the short-to-medium term to treat a condition caused by deficiency of the male sex hormone, according to the most comprehensive analysis of the treatment to date, published in The Lancet Healthy Longevity journal. The findings suggest that men given testosterone to treat hypogonadism...
Study identifies receptor that could alleviate need for chemo, radiation pre-T cell therapy
by University of California, Los Angeles a, Gating strategy for mass cytometry data to capture live, singlet CD8+ T cells from an in vitro T cell culture for downstream analysis of T cell phenotype and function. b, Gating strategy for mass cytometry data to capture tumor-infiltrating live, singlet CD8+ T cells for downstream analysis of...
Smoke break: New study strengthens link between smoking and increased fracture risk in men
by Keyonna Summers, University of Nevada, Las Vegas Credit: CC0 Public Domain It’s no secret that puffing cigarettes is the culprit behind a whole host of ailments, including respiratory diseases and cancers of the lungs and throat. But a new University of Nevada, Las Vegas (UNLV) study has revealed that male smokers—who, demographically, are more...
The largest ever series of phage therapy case studies shows a success rate of more than half
by Patrick Monahan, University of Pittsburgh Taken in the lab of Graham Hatfull at the University of Pittsburgh, this image shows a plate of bacteria — clear circles indicate where bacteriophages have done their work. The lab provides these bacteria-killing viruses to patients who have no other options to treat antibacterial-resistant infections. Credit: Aimee Obidzinski/University...
Gene variant gives mice super-powered tendons for jumping and running
by The Scripps Research Institute Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1systemic-mut/+, Piezo1tendon-mut/+, and Piezo1muscle-mut/+mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P < 0.05, **P < 0.01, ***P <...
Stem cell research reveals detailed genetic roadmap of glaucoma
by University of Melbourne Acute angle closure glaucoma of the right eye (intraocular pressure was 42 in the right eye). Credit: James Heilman, MD/Wikipedia A new, detailed genetic roadmap of glaucoma—the world’s leading cause of irreversible blindness—will help researchers develop new drugs to combat the disease, by identifying potential target areas to stall or reverse...
Protein discovery reinvigorates promising new therapeutic
by University of Texas at Austin A look at the structure of the SCF-based therapeutic. Credit: The University of Texas at Austin / Cockrell School of Engineering Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation...
Scientists discover intergenerational ‘memory’ mechanism of diabetes
by Zhejiang University Schematic diagram of maternal epigenetic mechanism of glucose intolerance caused by TET3 dysfunction. Credit: Team led by Prof. Huang Hefeng Symptomatic treatment has been a common approach to chronic diseases in the past. For example, diabetes is treated by controlling the increase of glucose and alleviating various diabetes-induced complications with insulin. How...
Binge drinking raises risk of developing alcohol problems, even for moderate drinkers
by Elsevier Credit: CC0 Public Domain Moderate drinkers who binge alcohol are at a significantly higher risk of developing alcohol problems than those who drink the same amount overall but don’t binge, according to a new study from researchers at The University of Texas at Austin appearing in the American Journal of Preventive Medicine. After analyzing...