by Ingrid Fadelli, Medical Xpress Immunofluorescent image of human ipsc-derived tri-culture, containing microglia (red), neurons (green), and astrocytes (purple). Nuclei are stained blue. These cultures were used to unravel the role of iron overload and ferroptosis in microglia in neurodegenerative disease. Credit: Ryan et al Past neuroscience research consistently found a link between deviations from the “normal”...
Will Pass January 12, 2023 Long COVID is typically characterized by anosmia and dysgeusia, cognitive impairment, dyspnea, weakness, and palpitations, with younger patients showing greatest improvements at 1 year, according to a nationwide cohort study conducted in Israel. These findings help define long COVID, guiding providers and patients through the recovery process, Barak Mizrahi, MSc, of KI Research Institute, Kfar...
by University of Veterinary Medicine—Vienna Genome-wide CRISPR/Cas9-based loss-of-function screen identifies genetic dependencies of STAT3Y640F-driven cells a) Schematic illustration of a competitive proliferation assay. b) Competitive proliferation assays of clonal Cas9-expressing STATY640F-driven HPC7 or c) clonal Cas9-HPC7 empty vector cells expressing IRF670 and sgRNAs targeting either Myb (positive control) or the Rosa26 locus (negative control). d)...
Laird Harrison January 12, 2023 The available evidence suggests that proton pump inhibitors (PPIs) do not cause gastric cancer, researchers say. The study could help resolve a controversy over one of the most serious side effects attributed to the widely used medications. “Our findings are reassuring, especially to all those patients who have an indication for long-term PPI use and...
Reviewed by Emily Henderson, B.Sc. Jan 3 2023 Announcing a new publication for Acta Materia Medica journal. Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external...
UNIVERSITY OF GALWAY IMAGE: THE PHOTOGRAPHS SHOW MRSA GROWING ON THE SURFACES OF TWO AGAR PLATES, ONE WITHOUT GUANOSINE (LEFT) AND ONE WITH GUANOSINE (RIGHT) ONTO WHICH DISKS SOAKED WITH ANTIBIOTICS HAVE BEEN APPLIED. THE ZONES OF CLEARING AROUND THE ANTIBIOTIC DISKS ARE INDICATIVE OF MRSA KILLING. CREDIT: UNIVERSITY OF GALWAY : Scientists at University of...
BAR-ILAN UNIVERSITY IMAGE: CANCER CELLS USE FEET-LIKE PROTRUSIONS CALLED INVADOPODIA TO DEGRADE UNDERLYING TISSUE, ENTER THE BLOODSTREAM AND FORM METASTASES IN OTHER ORGANS. APPROXIMATELY FOUR YEARS AGO DR. HAVA GIL-HENN AND RESEARCHERS FROM THE AZRIELI FACULTY OF MEDICINE OF BAR-ILAN UNIVERSITY REVEALED TWO IMPORTANT CLUES ABOUT THE FORMATION OF INVADOPODIA: THE CELLULAR LEVEL OF THE...
BRIGHAM AND WOMEN’S HOSPITAL Researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, have found new evidence that vitamin D may be metabolized differently in people with an elevated body mass index (BMI). The study, appearing in JAMA Network Open, is a new analysis of data from the VITAL trial, a large...
by University of California – San Diego Tumor-initiating cells (blue) produce an extracellular matrix containing fibronectin (pink) which gives them increased stress tolerance, drug resistance and tumor-initiating properties. Credit: UC San Diego Health Sciences Researchers at University of California San Diego School of Medicine have discovered a molecular pathway critical to the initiation of pancreatic tumors....
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) The analysis of human samples and animal experiments demonstrate that the presence of p53 gene mutations in the blood increases the risk of developing atherosclerosis, the principle cause of cardiovascular disease. Credit: CNIC A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration...
