by Cristy Lytal, University of Southern California Credit: CC0 Public Domain A new study in Aging Cell describes how a key protein called Signal Transducer and Activator of Transcription 3 (STAT3) might turn back the clock on aging cartilage that leads to osteoarthritis. “STAT3 performs an astonishing repertoire of roles in development and regeneration, as well as...
by Leiden University Tumor-infiltrating Vδ1 and Vδ3 T cell subsets display hallmarks of cytotoxic activity in MMR-d colon cancers. a, UMAP embedding showing the clustering of γδ T cells (n = 4,442) isolated from MMR-d colon cancers (n = 5) analyzed using scRNA-seq. The colors represent the TCR Vδ chain usage. Dots represent single cells. b, The frequencies of...
by Josep Carreras Leukaemia Research Institute Comparative in vitro study of engineered CD1a-STAb and CD1a-CAR T cells. (A, B) Schematic diagrams showing the genetic (A) and domain structure (B) of the CD1a-TCE bearing a signal peptide from the human κ light chain signal peptide (S, gray box), the anti-CD1a scFv gene (orange boxes), the anti-CD3...
by Medical College of Georgia at Augusta University Dr. Ravindra Kolhe. Credit: Michael Holahan, Augusta University Technology that enables an unprecedented, high-resolution look for all structural variants in our genes that are known to cause cancer can outperform standard tests used today for common blood cancers like leukemia, researchers report. It’s called optical genome mapping, or OGM,...
by Bob Yirka, Medical Xpress Graphical abstract. Credit: Cell Reports Medicine (2023). DOI: 10.1016/j.xcrm.2022.100895 At team of researchers at Stanford University reports evidence that people who engage in cyclic sighing breathing exercises see a greater reduction in stress than those engaging in mindfulness meditation. In their paper published in the journal Cell Reports Medicine, the researchers describe their study of several different...
by Bob Yirka, Medical Xpress Hypothesized mechanisms of long COVID pathogenesis. There are several hypothesized mechanisms for long COVID pathogenesis, including immune dysregulation, microbiota disruption, autoimmunity, clotting and endothelial abnormality, and dysfunctional neurological signaling. EBV, Epstein–Barr virus; HHV-6, human herpesvirus 6; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Credit: Nature Reviews Microbiology (2023). DOI: 10.1038/s41579-022-00846-2 A small team of researchers,...
by University of Jyväskylä Credit: University of Jyväskylä A study conducted at the University of Jyväskylä found that women with larger muscle mass had lower arterial stiffness from youth to middle age. The study also revealed that hypertension was the most significant predictive factor for arterial stiffness regardless of age. Researchers also found that even good aerobic...
Reviewed by Emily Henderson, B.Sc. Jan 16 2023 RUDN University chemists, biologists and physicians have found a simple way to predict the properties of compounds of drugs with metals. This can be done using topological indices – numbers that describe the structure of the molecule. The results will help finding new metal complexes that will...
In a first for the genetic toolset known as CRISPR, a recently discovered protein has been found to act as a kind of multipurpose self-destruct system for bacteria, capable of degrading single-stranded RNA, single-stranded DNA and double-stranded DNA. With its abilities to target so many types of genetic material, the discovery holds potential for the development...
Seizures are suddenly triggered by stress, fever, flashing lights, or tiredness. Some cause the body to jerk and shake while others can produce strange sensations, make one lose a sense of awareness, or faint. They can happen when the person is awake or asleep. When they pass, after a few seconds or minutes, they leave people tired,...
