UNIVERSITY OF HELSINKI Researchers have uncovered sphingolipid accumulation as a new mechanism that affects ageing. Ceramides, the best-known class of sphingolipids, accumulate in aged muscle, impairing its function while also affecting functional capacity in older adults. These findings encourage researchers to develop potential pharmaceutical agents. A study carried out at the University of Helsinki and...
Month: <span>January 2023</span>
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The nose knows: study suggests it may be wise to screen for smell loss to predict frailty and unhealthy aging
JOHNS HOPKINS MEDICINE FOR IMMEDIATE RELEASE In a study using data from nearly 1,200 older adults, Johns Hopkins Medicine researchers have added to a growing body of evidence that loss of the sense of smell is a predictive marker for an increased risk of frailty as people age. Building on previous research showing that olfactory dysfunction is a common...
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Anticancer drugs: a new hope for sepsis treatment
INSTITUTO GULBENKIAN DE CIENCIA The body’s extreme response to infection, a condition called sepsis, kills 11 million people every year. This is because to survive a serious infection it is not enough to get rid of the infectious agent, which is currently done with relative effectiveness; it is also necessary to limit the damage these and the immune response cause on the organs....
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New hormonal agent may slow progression of early-stage prostate cancer during active surveillance
WOLTERS KLUWER HEALTH January 10, 2023 – For men with early-stage prostate cancer being managed by active surveillance, adding the hormonal agent apalutamide may lower the rate of positive biopsies during follow-up, suggests a preliminary clinical trial in The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters...
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Shockwave intravascular lithotripsy-assisted TMVR shows promise for patients with severe stenosis and regurgitation
SOCIETY FOR CARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS WASHINGTON (January 10, 2023) – In recent years, transcatheter mitral valve replacement (TMVR) treatment and technology has evolved, but procedure-related morbidity remains a concern. A new study published today in the Journal of the Society for Cardiovascular Angiography & Interventions (JSCAI) shows promise for intravascular lithotripsy (IVL)-assisted TMVR to treat a severely...
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Mouse model shows obesity in early life promotes later inflammatory disease, even after weight loss
by Bob Yirka, Medical Xpress Credit: CC0 Public Domain A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in...
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Mapping endometriosis: A vast cellular atlas is created
by Cedars-Sinai Medical Center Credit: Pixabay/CC0 Public Domain Investigators at Cedars-Sinai have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease. The study is published today in the journal Nature Genetics. “Endometriosis has been an understudied disease in part because of limited...
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Study examines brain aging in people with schizophrenia
by CORDIS Correlation coefficients of predicted brain age and FreeSurfer features across control and schizophrenia (SZ) groups. Bivariate correlations are shown to provide an indication of the relative contribution of features in brain age prediction. The figure shows Pearson correlations between predicted brain age and cortical thickness features (top row), cortical surface areas (middle row)...
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Frequent use of antibiotics may heighten inflammatory bowel disease risk in adults over 40
by British Medical Journal Credit: Pixabay/CC0 Public Domain Frequent use of antibiotics may heighten the risk of inflammatory bowel disease—Crohn’s disease and ulcerative colitis—among adults over 40, suggests research published online in the journal Gut. The risk seems to be cumulative and greatest 1-2 years after use and for those antibiotics targeting gut infections, the findings indicate. Mounting...
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Consumption of fast food linked to liver disease
by University of Southern California Credit: Maliz Ong/public domain The new year has begun, and with it, resolutions for change. A study from Keck Medicine of USC published today in Clinical Gastroenterology and Hepatology gives people extra motivation to reduce fast-food consumption. The study found that eating fast food is associated with nonalcoholic fatty liver disease, a potentially life-threatening condition in...