by Kiel University In AML, an early precursor of the so-called myeloid cells degenerates; these so-called blasts (in purple, 63x magnification) subsequently multiply uncontrollably. Credit: Dr. med. Lars Fransecky, UKSH Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system that originates from immature precursors of red blood cells, platelets and part of...
Study shows that the lateral orbitofrontal cortex ‘writes’ cognitive maps in the brain
by Ingrid Fadelli, Medical Xpress Credit: Max Pixel, CC0 Public Domain The orbitofrontal cortex (OFC) is a region in the frontal lobe of the brain known to be involved in decision-making and information processing. The lateral part of this brain region, known as the lOFC, has been identified as a particularly salient region for the...
To rev-up CAR T-cell therapy, inhibit the SUSD2 membrane protein, study suggests
by Ohio State University Medical Center Credit: Pixabay/CC0 Public Domain Inhibiting a particular protein in cancer-killing immune cells might improve the long-term effectiveness of CAR T-cell and other immune checkpoint therapies, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James). Published in...
Altered speech may be the first sign of Parkinson’s disease
KAUNAS UNIVERSITY OF TECHNOLOGY IMAGE: DR RYTIS MASKELIŪNAS, A RESEARCHER AT KAUNAS UNIVERSITY OF TECHNOLOGY, KTU CREDIT: KTU The diagnosis of Parkinson’s disease has shaken many lives. More than 10 million people worldwide are living with it. There is no cure, but if symptoms are noticed early, the disease can be controlled. As Parkinson’s disease progresses, along...
New DNA biosensor could unlock powerful, low-cost clinical diagnostics
NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY (NIST) IMAGE: IN A NEW STUDY, RESEARCHERS DEMONSTRATE THE CAPABILITY OF DNA BIOSENSOR COMPONENTS FOR A UNIQUE MODULAR DNA BIOSENSOR. THE RESEARCHERS PLAN TO INTEGRATE THEIR DESIGN WITHIN A DEVICE THE SIZE AND SHAPE OF A SMARTPHONE FOR LOW-COST CLINICAL DIAGNOSTICS. CREDIT: N. HANACEK/NIST DNA can signal the presence...
Color images from the shadow of a sample
UNIVERSITY OF GÖTTINGEN IMAGE: ARTISTIC REPRESENTATION SHOWING HOW AN IMAGE IS CREATED USING THE NEWLY DEVELOPED METHOD. TWO COLOURS – GREEN AND MAGENTA – ARE EMITTED BY FLUORESCING ATOMS IN THE SAMPLE (LEFT) DUE TO X-RAY EXCITATION. THE GREY ROUND OBJECT REPRESENTS AN OPTIC CASTING A SHADOW ON THE DETECTOR. THE ALGORITHM THEN PRODUCES AN...
Novel microneedle bandage could save lives by stopping blood loss from wounds
PENN STATE IMAGE: HEMOSTATIC MICRONEEDLE TECHNOLOGY CAN BE APPLIED LIKE A TYPICAL ADHESIVE BANDAGE TO QUICKLY STOP BLEEDING. THE BIOCOMPATIBLE AND BIODEGRADABLE MICRONEEDLE ARRAYS (MNAS) ON THE PATCH INCREASE ITS SURFACE CONTACT WITH BLOOD TO ACCELERATE THE CLOTTING PROCESS AND ALSO INCREASE THE ADHESIVE PROPERTIES OF THE PATCH VIA MECHANICAL INTERLOCKING TO PROMOTE WOUND CLOSURE....
Propionic acid protects nerve cells and helps them regenerate, shows study
by Julia Weiler, Ruhr-Universitaet-Bochum Nerve cell growth with (left) and without the administration of propionate (right). Credit: Dr. Thomas Grüter und Niklas Rilke Some autoimmune diseases attack the nerves in the arms and legs. Bochum-based researchers are pursuing a new approach to counteracting this damage. Researchers at St. Josef Hospital Bochum have shown in lab experiments that propionate,...
How cancer cells die: Scientists explore new pathways of pyroptosis, killer kin of apoptosis
by Delthia Ricks, Medical Xpress Lymphoid BLaER1 cells undergo PANX1-dominant lysis. (A to C) BLaER1 cells were treated with topoisomerase poisons doxorubicin (2 μM) or etoposide (50 μM) for 24 hours. Concurrent treatment with PANX1 inhibitor trovafloxacin (20 μM) or NLRP3 inflammasome inhibitor MCC950 (10 μM) were as indicated. In (A and C), quantification of...
MedPaLM: New AI Medical Chatbots Will Soon Be Better Than Waiting For A Doctor
The Medical Futurist | 3 min | 17 January 2023 Large language models (LLMs), these excitingly versatile algorithms became a topic of general conversation in December 2022, when OpenAI released its GPT3 agent, also known as ChatGPT. LLMs are developed to carry on conversations in human-like ways, they are designed to understand complex queries and...