by Osaka University TGCV is an emerging cardiovascular disorder characterized by diffuse narrowing coronary atherosclerosis with triglyceride (TG) deposition caused by defective intracellular lipolysis. TGCV is an often-undiagnosed condition in patients who are resistant to standard therapies. Panels A and B concern two patients in their 60s with refractory angina pectoris and diabetes mellitus. After...
by Ola Nilsson, Umea University Release of vesicles with transduction proteins in electron microscope magnification. Credit: Devendra Kumar Maurya Researchers at Umeå University have discovered a previously unknown cellular component, an organelle, inside neurons that we use to perceive smell. The discovery may have implications for further research on impaired sense of smell, which is a common symptom...
BY JOSEPH GUSTAITIS | DECEMBER 30, 2022 Metformin, the most popular blood sugar-lowering medicine in the world, seems to be turning out to be the Swiss Army knife of medications. In recent years, there have been reports that metformin appears to improve mitochondrial function in people with diabetes, that it can help in chronic kidney disease (CKD), and...
Could a two-drug combination improve treatment response in late-stage melanoma? Glasshouse Images/Getty Images Researchers tested the efficacy of a drug combination for treating stage IV melanoma. They found that 71% of patients responded to the drug combination, and 50% had complete remission. The drug combination is now entering a larger trial with a more diverse cohort....
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)— Atherosclerosis is a long-term arterial vessel wall disease characterized by the build- up of lipid- rich and inflamed plaques. It often goes undetected, but highly inflamed plaques disrupt and form a blood clot attached to the vessel wall adjacent to the flowing blood. This acute event (atherothrombosis) can lead...
Stem cells overflow with potential. Their ability to become other cell types is crucial to our bodies during development and throughout life. But this potential can be our downfall if it goes wrong, turning some of our most useful cells into malignant cancers. While investigating a pathway involved in stem cell differentiation, researchers at UC Santa Barbara found...
by Cara Murez COVID-19 patients could soon have a new antiviral pill they can take to guard against severe disease. The treatment, called VV116, worked as well as Paxlovid in people who were at high risk of severe disease in a phase 3 trial in China. The trial was a “great success,” study co-author Ren Zhao, a...
by University of California – San Diego This image was generated by artificial intelligence based upon a request for 3D art using a natural language interpretation of “artificial intelligence that detects mutations in the genome.” Credit: Joseph Gleeson/UC San Diego Genetic mutations cause hundreds of unsolved and untreatable disorders. Among them, DNA mutations in a...
By ROGER DOBSON FOR THE DAILY MAIL PUBLISHED: 20:10 EST, 2 January 2023 | UPDATED: 20:12 EST, 2 January 2023 A tiny plug placed in a tear duct could mean the end of daily drops for patients with dry eyes. The high-tech plug — the size of a grain of rice — continuously releases anti-inflammatory medication for three months. It’s...
KATERYNA KON/SCIENCE PHOTO LIBRARY VIA GETTY This article is from The Checkup, MIT Technology Review’s weekly biotech newsletter. We’re all crawling with bugs. Our bodies are home to plenty of distinct ecosystems that are home to microbes, fungi, and other organisms. They are crucial to our well-being. Shifts in the microbiome have been linked to...
