by Ramona Czakert Franson, University of Alberta Credit: Pixabay/CC0 Public Domain Scientists at the University of Alberta have discovered that important risk factors in Alzheimer’s disease affect males and females very differently. “Two types of risk for Alzheimer’s disease work differently for males and females, and dramatically so,” says Mackenzie Heal, neuroscience master’s student in...
by Nationwide Children’s Hospital Graphical abstract. Credit: Circulation Research (2022). DOI: 10.1161/CIRCRESAHA.122.321398 A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital heart defects in humans. In 2005, Vidu Garg, MD, a pediatric cardiologist...
by University of Bristol Credit: Pixabay/CC0 Public Domain An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart’s biological age by 10 years. The breakthrough, published in Cardiovascular Research and led by scientists at the University of Bristol and the MultiMedica Group in Italy, offers a potential target for...
by Hudson Institute of Medical Research Dr Mohamed Saad. Credit: Hudson Institute of Medical Research It’s a disease in search of a remedy, but Hudson Institute researchers have identified a new pancreatitis treatment target, giving hope to sufferers worldwide. Pancreatitis is a serious inflammatory gastrointestinal disorder which can lead to severe conditions, with as many as 20% of patients...
by Kelcey Buck, University of Nebraska-Lincoln RNAScope analysis of M cell marker gene expression in taste cells. RNAscope Hiplex fluorescence assay was used to determine the coexpression of Spib (A-D), Gp2 (E-H), and Tnfrsf11a (I-L) with the taste cell markers Tas1r3, Gnat3, Trpm5, and Ddc in the CVP. Strong coexpression of Spib is observed with...
by Matt Shipman, North Carolina State University High-speed endovascular sonothrombolysis with vortex ultrasound-induced shear stress. a, The schematic view of the sonothrombolysis process with a vortex ultrasound transducer. The vortex ultrasound transducer is installed in a 9-Fr catheter and inserted into the blood vessel with a blood clot. The microbubble cavitation agents are injected through...
by Instituto de Medicina Molecular Grphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01243 A new study led by Gonçalo Bernardes, group leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and Professor at the University of Cambridge (Cambridge, UK), published recently in the journal ACS Central Science, reports the discovery of a compound efficient...
by Vanderbilt University Medical Center Identification of a unique heterozygous mutation in the IRF4 gene in seven CID patients. Credit: Science Immunology (2023). DOI: 10.1126/sciimmunol.ade7953 An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, Ph.D., has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia....
by Anne Trafton, Massachusetts Institute of Technology Data from the human Grade 1 HD patient indicate the loss of compartmental identities as a conserved signature of HD. Credit: Nature Communications (2023). DOI: 10.1038/s41467-022-35752-x In patients with Huntington’s disease, neurons in a part of the brain called the striatum are among the hardest-hit. Degeneration of these neurons contributes...
by Michael Miller, University of Cincinnati Methods for the extraction of ISF. a, Wick extraction inserts an absorbent wicking material into the dermis and relies on capillary action to saturate the wick with whole ISF or analytes for subsequent analysis. b, Suction blisters are induced by applying negative pressure to the dermis. The fluid within these blisters...
