by European Society of Cardiology Credit: Pixabay/CC0 Public Domain An innovative three-step ablation approach including ethanol infusion of the vein of Marshall improves freedom from arrhythmias in patients with persistent atrial fibrillation compared to pulmonary vein isolation (PVI) alone, according to late breaking science presented at EHRA 2023. Preliminary results at 10 months are presented, with follow...
by Andy Fell, UC Davis Salmonella bacteria (red) cause up to a million deaths a year worldwide and there is a need for effective vaccines. New work from UC Davis shows how salmonella-specific T-cells can be stimulated to take up residence in the liver, ready to quickly fight off the infection. Credit: Rocky Mountain Laboratories, NIAID,...
by Cedars-Sinai Medical Center Credit: CC0 Public Domain Vitamin D deficiency could be the reason African American men experience more aggressive prostate cancer at a younger age compared with European American men, new research from Cedars-Sinai Cancer suggests. The multi-institutional study, published today in Cancer Research Communications, could pave the way for revised nutritional guidelines. While...
by RIKEN Graphical abstract. Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2022.12.013 RIKEN researchers have discovered how a species of gut microbe exacerbates obesity in mice fed a high-fat diet. Now published in Cell Metabolism, this finding could help scientists develop new ways of treating obesity via the microbiome. Obesity, which is a major risk factor for other metabolic disorders such as type 2 diabetes,...
by Spectrum Health Prakash Chinnaiyan, M.D., a physician scientist in the Department of Radiation Oncology at Corewell Health in Southeast, Mich. Credit: Elizabeth Debeliso, Corewell Health For decades, researchers have marveled at the ability of glioblastoma, a particularly aggressive brain cancer, to turn off a patient’s cancer-fighting immune cells, thereby allowing tumors to grow freely. This remains...
by Bob Yirka, Medical Xpress ML-based COPD GWAS Manhattan plot via DeepNull. We performed ML-based COPD GWAS where we used the same set of covariates as the Fig. 4 with one additional covariate provided by DeepNull. DeepNull model predicts the ML-based COPD using age, sex, genotype-array, and FEV1/FVC as inputs. The additional DeepNull-covariate is the...
Laird Harrison January 12, 2023 The available evidence suggests that proton pump inhibitors (PPIs) do not cause gastric cancer, researchers say. The study could help resolve a controversy over one of the most serious side effects attributed to the widely used medications. “Our findings are reassuring, especially to all those patients who have an indication for long-term PPI use...
M. Alexander Otto, PA, MMS January 18, 2023 A randomized clinical trial from India raises the possibility of huge cost savings by using much lower doses of immunotherapy. The researchers used just 6% of the recommended dose of nivolumab instead of the full dose in their treatment of patients with advanced head and neck cancer, and the addition of...
Asher Mullard In people with amyotrophic lateral sclerosis (ALS), motor neurons, which help to send commands from the brain to muscle cells, become damaged, as depicted in this artist rendering.Credit: Kateryna Kon/Science Photo Library The US Food and Drug Administration (FDA) is set to rule soon on the approval of a new drug for a...
Tiny circles of DNA harbor cancer-associated oncogenes and immunomodulatory genes promoting cancer development. They arise during transformation from pre-cancer to cancer, say Stanford Medicine-led team. Tiny circles of DNA that defy the accepted laws of genetics are key drivers of cancer formation, according to an international study led by researchers at Stanford Medicine. The circles called extrachromosomal...
