by Max Planck Society Mental health and that of our cardiovascular system have a complex interaction. Credit: Blueastro/Shutterstock.com Our mental health and that of our cardiovascular system have a complex interaction. A recent study from the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig, Germany, now shows the links between higher...
by University College London 3D Extravasation assay for probing mechanics of cancer cells, endothelium, and the underlying ECM. a) Schematic representation of the extravasation assay. b) Quantification of the permeability of the HUVECs monolayer (magenta) formed on top of a thin collagen substrate. The permeability was calculated by measuring the changes of 70 kDa dextran (green) intensity...
by Mark Derewicz, University of North Carolina at Chapel Hill School of Medicine Patient with Myasthenia Gravis. Credit: Cumulus at Dutch Wikipedia, CC BY-SA 3.0 , via Wikimedia Commons The Lancet Neurology has published data from the phase 3 MycarinG study evaluating the efficacy and safety of rozanolixizumab in adult patients with acetylcholine receptor autoantibody-positive (AChR-Ab+) or muscle-specific...
by The Ottawa Hospital Dr. Dean Fergusson holding a unit of blood. Credit: The Ottawa Hospital A large clinical trial of more than 8,700 patients published in the New England Journal of Medicine concluded that the sex of a donor has no effect on the survival of recipients of red blood cell transfusions. “Some observational studies had suggested...
by UT Southwestern Medical Center Association of baseline acoustic (panel A) and lexical-semantic (panel B) scores with the 2-year change of CDR-SOB (higher value indicates greater disease progression). X-axis is the derived digital biomarker score. Y-axis is the change in CDR-SOB over 2 years. Higher baseline acoustic score and lower lexical-semantic scores were associated with greater...
by Bill Snyder, Vanderbilt University Medical Center Credit: Unsplash/CC0 Public Domain An international coalition of biomedical researchers co-led by Alexander Bick, MD, Ph.D., at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer....
by Corey Binns, Stanford University Overview of a GMAI model pipeline. a, A GMAI model is trained on multiple medical data modalities, through techniques such as self-supervised learning. To enable flexible interactions, data modalities such as images or data from EHRs can be paired with language, either in the form of text or speech data. Next,...
by Lancet Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A technique that identifies the build-up of abnormal protein deposits linked to Parkinson’s disease could aid in early detection and play a key role in the disease’s clinical diagnosis and characterization, according to research published in The...
by Anne Trafton, Massachusetts Institute of Technology In the brains of mice treated with the new peptide (two right panels), many fewer Tau proteins (stained purple) are seen in the top right. The left panels show neurons from mice treated with a scrambled version of the peptide. In the two bottom panels, DNA in the cell...
Gemma Conroy RNA polymerase (blue) unwinds DNA (violet), using it as a template to produce a strand of messenger RNA (red). In aged cells, this process accelerates.Credit: selvanegra/Getty Ageing seems to affect cellular processes in the same way across five very different kinds of life — humans, fruit flies, rats, mice and worms — according...
