by Walter and Eliza Hall Institute of Medical Research Hematological and iron markers are similar in PV patients with and without history of venesection. (A) Hematocrit (HCT); (B) red blood cell count (RBC); (C) ferritin; (D) transferrin saturation; (E) serum hepcidin; (F) serum ERFE, (G) hepcidin:ferritin ratio, (H) platelet count and (I) leukocyte count in...
Month: <span>April 2023</span>
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Study provides the first precise insight into important remodeling processes in adipose tissue
by University of Bonn Fat droplets in the fat cell of a mouse: The membrane of the droplets was stained green, and the fat stored in them was stained red. Credit: Johanna Spandl / University of Bonn Fat molecules serve as energy storage for fat cells. They consist of three fatty acids attached to a...
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A 21st-century remedy for missed meds could deliver time-released drugs, vaccines for months
by Jade Boyd, Rice University Sealed microparticles containing colored dye are shown inside the narrow opening of a standard-sized hypodermic needle. Credit: Brandon Martin/Rice University Missing crucial doses of medicines and vaccines could become a thing of the past thanks to Rice University bioengineers’ next-level technology for making time-released drugs. “This is a huge problem...
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Developing lipid nanoparticles to carry mRNA specifically to the pancreas
Reviewed by Emily Henderson, B.Sc. Mar 31 2023 Therapeutics that use mRNA-; like some of the COVID-19 vaccines-;have enormous potential for the prevention and treatment of many diseases. These therapeutics work by shuttling mRNA ‘instructions’ into target cells, providing them with a blueprint to make specific proteins. These proteins could help tissues to regenerate, replace...
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A Key Process in How the Brain Consolidates Memories
Summary: Researchers have identified a molecular process involved in gene expression in neurons which appears to play a key role in memory consolidation. Source: UC Davis The process by which memories are formed in the hippocampus region of the brain is complex. It relies on a precise choreography of interactions between neurons, neurotransmitters, receptors and enzymes. A...
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Study identifies how microbiome may affect pancreatic cancer outcomes
by Tim Tedeschi, University of Cincinnati Bacterial species diversity in long-term survivors (LTSs) versus controls. (A) Principal coordinates ordination performed on the species-level Bray-Curtis dissimilarity for LTSs and controls. (B) Shannon and Simpson indices for species diversity in LTSs versus controls. Credit: Cancer (2023). DOI: 10.1002/cncr.34748 Even as pancreatic cancer treatments improve, only about 9% of patients survive past five...
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How two different types of immune cells help two billion people keep tuberculosis in check
by University of Chicago Credit: Pixabay/CC0 Public Domain More than 10 million people are sickened by tuberculosis (TB) globally each year, resulting in 1.5 million deaths. Yet, as many as two billion people are infected with Mycobaterium tuberculosis, the bacterium that causes tuberculosis, and are otherwise healthy and asymptomatic. Scientists who study TB look at those...
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Early menopause, later start to hormone therapy may increase risk of Alzheimer’s disease
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Women are more likely than men to develop Alzheimer’s disease (AD), with women making up two-thirds of the population living with AD. A new study, led by Mass General Brigham researchers, sheds light on the relationship between the risk of Alzheimer’s disease and age of menopause and use...
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Combination therapy a promising option for advanced kidney cancer patients already treated with immunotherapy
by Dana-Farber Cancer Institute Credit: Unsplash/CC0 Public Domain Immunotherapies, such as anti-PD-1 and anti-PD-L1, have become standard first line therapies for patients with advanced renal cell carcinoma (kidney cancer). Most patients, however, eventually experience disease progression, with no consensus on what therapy to use next. In an open-label phase 2 study, led by Dana-Farber Cancer...
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Study: Metformin and leucine prevent cellular senescence and proteostasis disruption
by Impact Journals LLC Summary schematic of MET+LEU effects during SD in muscle cells. Credit: 2023 Petrocelli et al. Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, researchers found that...