Credit: Unsplash/CC0 Public Domain Lactate will be familiar to many due to a common belief that it causes muscle “burn” following exercise—but this is a myth. Lactate is formed in our muscles during exercise, but this is not the only source of it in our bodies. It is also produced by many of the microbes that...
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Does Higher Spending On Primary Care Lead To Lower Total Health Care Spending?
High-quality primary care is the foundation of a high-functioning health care system. It ensures patients have access to essential services, prevents emergency department visits and hospital admissions, leads to better health outcomes, and improves quality of care and equity. The secret sauce that allows high-quality primary care to deliver on all these benefits is long-term relationships between patients...
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Metformin: An Unexpected Ally Against Long COVID?
Metformin use in adults with type 2 diabetes (T2D) is associated with a slightly lower incidence of long COVID and death within 180 days after SARS-CoV-2 infection. METHODOLOGY: TAKEAWAY: IN PRACTICE: “The incidence of PASC was lower when defined by [International Classification of Diseases] code compared with a computable phenotype in both databases,” the authors...
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How can you help your child learn to self-regulate?
Credit: Allan Mas from Pexels Throughout our lives, we need to be able to manage our thoughts and behavior. We need to do this to reach various goals and to get along with others—even if other distractions and impulses get in the way. This is our ability to self-regulate, and it starts to develop between the...
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Researchers identify signaling mechanism that damages cells in diabetic kidney disease
Researchers identify signaling mechanism that damages cells in diabetic kidney diseaseUpregulation of FXII correlates with impaired kidney function in human DKD. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52214-8Diabetic kidney disease, a complication of diabetes, is considered the leading cause of chronic kidney disease and kidney failure worldwide. It is associated with changes in the structure and...
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Disrupting Asxl1 gene prevents T-cell exhaustion to improve immunotherapy, researchers discover
Core epigenetic regulators in maintaining therapeutic durable multipotent Tpex populations. Credit: Science (2024). DOI: 10.1126/science.adl4492 Immunotherapy, using a patient’s own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most. New research from St. Jude Children’s Research Hospital and colleagues has found that disrupting Asxl1, a gene in...
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Protein blocking bone development could hold clues for future osteoporosis treatment
Credit: CC0 Public Domain Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation. In their paper published in Communications Biology 11 October 2024, a team of researchers led by Dr. Amy Naylor and Professor Roy Bicknell along with their team...
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Inducing a gene that informs cell signaling could halt diabetic kidney disease, study shows
Immunofluorescence image of the proximal tubule (in green), surrounding the glomeruli in the kidney with the activated calcium/calmodulin-dependent protein kinase 1 (CaMK1D), in red. Blue indicates cells in the kidney. Credit: Sandeep K. Mallipattu and Nehaben A. Gujarati New research by Stony Brook Medicine nephrology specialists that centers on targeting key cellular signaling between two...
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New study challenges longstanding assumption about the cause of the genome’s most common mutation
The PER-seq measured error signature of Pol ε P286R resembles the mutational spectrum and mutational signatures of POLEd and MMRd human cancers. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01945-x A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many...
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Magnetically regulated gene therapy tech offers precise brain-circuit control
A gene therapy allows precise magnetic field control of specific brain circuits without implanted devices. The image shows restricted mRNA expression of the genetically encoded magnetic sensor (red) in dopaminergic neurons type 2 (green) in the mouse striatum that regulate initiation of movement. Dopaminergic neurons type 1 (cyan) and cell nuclei shown with dapi staining...