Brigham researchers have found that people with wide-ranging long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in their blood, compared to those without long COVID symptoms. A persistent infection could explain why some people experience long COVID symptoms, according to a new study led by researchers at Brigham and Women’s Hospital. The team found...
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Newly discovered COVID vaccine targets may last longer
Workflow for the generation of SARS-CoV-2-derived HLA I and HLA II immunopeptidome data. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-51959-6 Melbourne researchers have discovered more than 200 new vaccine target candidates from the COVID-19 virus, SARS-CoV-2, that could lead to the development of vaccines with a longer lasting broader immunity than existing vaccinations. In a paper published in the journal Nature...
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Fatty acids found in meat and poultry may be beneficial to human metabolism
Purdue University’s James Markworth, assistant professor of animal sciences, and Ph.D. student Xinyue Lu observe results of immunofluorescent staining of a cross-sectional sample of skeletal muscle tissue stained with a cocktail of primary antibodies for muscle fiber type analysis. Muscle cells (myofibers) of differing contractile type, such as fast vs. slow twitch fibers, are distinguished...
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Ghost Fat: The Unseen Consequences of Weight Loss
612 Many people who lose weight, whether through diet and lifestyle changes, medication, or bariatric surgery, recognize their body has changed. While they also experience improvements in quality of life and psychosocial areas, that’s not true for everyone. Some patients don’t “see” they’ve lost weight — a phenomenon referred to as “phantom fat,” “ghost fat,” or “vestigial body image.”...
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Failure in a CAR T cell trial could unlock multiple treatments for acute myeloid leukemia
AML exposure to cytokines results in CART-123 exhaustion. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03271-5 In the clinical battle against leukemia, recent breakthroughs in chimeric antigen receptor T cells (CAR T) have given patients and doctors an unprecedented weapon. CAR T cell therapy has demonstrated efficacy in treating B-cell malignancies, achieving high response rates and durable remissions. However,...
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Three Tips to Avoid Common Diagnostic Errors in Primary Care
Common complaints of abdominal pain, fever, shortness of breath, or rash can signal more serious disease that should be referred to specialty care or might be related to benign conditions. Combine the vague nature of many patients’ descriptions and the pressure of short visits, and clinicians have a recipe for all manner of diagnostic error....
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Kids should play outside more to reduce the risk of short-sightedness and potential adult blindness, say researchers
Angus Greeff, 8, was diagnosed with myopia aged two and, thanks to Lions Eye Institute intervention, hopes to become a professional cricketer when he grows up. Credit: The Lions Eye Institute For most people with myopia, being short-sighted is an inconvenience. However, for some, myopia can lead to blindness. Ahead of World Sight Day (10...
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Cell line models identify cause of melanoma with drug resistance
AMD1 inactivation sensitizes BRAF mutant melanoma to vemurafenib. Credit: Molecular Cancer (2024). DOI: 10.1186/s12943-024-02031-w Melanoma is a type of cancer that originates from melanocytes, the cells responsible for producing skin pigment, and is known as the most lethal form of skin cancer due to its high rates of metastasis and recurrence. With the global trend of aging...
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New technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
A clonal competition assay showing populations of cells with different mutations. Depending on the mutation, each population of cells is stained a different color. Credit: Larissa Haertle / CNIO Not all cells within the same cancer are the same. They all have genetic errors that turn them into tumor cells, but these errors are not...
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Research suggests a new strategy for people with type 1 diabetes to lower blood sugar after exercise
(A) Twenty-four-hour post-exercise continuous glucose monitoring (CGM). Each grey line represents 1 participant’s CGM trace for the 24-hour post-exercise period. (B) Comparison of 24-hour post-exercise median sensor glucose. Credit: Canadian Journal of Diabetes (2024). DOI: 10.1016/j.jcjd.2024.05.001 Adults with type 1 diabetes should perform aerobic cooldowns to manage high blood sugar after intense exercise where glucose levels might rise,...