The accumulation of fats in the liver is driven by high-fat diets and obesity, and is becoming an increasingly prevalent global health concern. Characterized by excessive fat accumulation in the liver, this condition poses significant risks for various metabolic disorders. While much of the existing research has focused on fat metabolism within the liver itself,...
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Brain network study reveals clues about dementia’s behavior changes
Tau protein buildup in brain disrupts the salience network that connects multiple brain regions and helps us react to the outside world and our own thoughts Peer-Reviewed Publication Michigan Medicine – University of Michigan In this image created by averaging brain scans from hundreds of participants, purple spheres show the locations in the brain linked...
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New model shows potential for human papillomavirus vaccination switch to 1-dose gender-neutral approach
Canadian vaccination programs could switch to a 1-dose gender-neutral human papillomavirus (HPV) vaccination approach and eliminate cervical cancer, suggests new modeling in Canadian Medical Association Journal. “Our results have important policy implications in Canada, and in other similar high-income countries evaluating whether to switch to 1-dose HPV vaccination,” writes Dr. Marc Brisson, a full professor at...
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Poor blood circulation: How to prevent it, how to spot it
Pain, tingling and cramps in your legs and feet may be giving you a warning. They could be signs of poor blood circulation, which can lead to serious heart and health problems if left untreated, according to a doctor at Baylor College of Medicine in Houston. “Blood delivers oxygen and other important nutrients to the...
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Bright light therapy found to be effective for nonseasonal depressive disorders
Bright light therapy (BLT) is an effective adjunctive treatment for nonseasonal depressive disorder, according to a review published online Oct. 2 in JAMA Psychiatry. Artur Menegaz de Almeida, from the Federal University of Mato Grosso in Sinop, Brazil, and colleagues conducted a systematic review and meta-analysis to examine the effectiveness of BLT as an adjunctive treatment for nonseasonal depressive disorders....
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A free drug experiment bypasses the US health system’s secret fees
Credit: Unsplash/CC0 Public Domain A top California health plan is set to offer one of the world’s biggest-selling drugs for free in a bid to show the medicine can reach Americans affordably without going through the middlemen that typically control its flow. Blue Shield of California struck an unusual deal to buy a lower-cost version...
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Discovery of key gene offers new hope in treating chronic myeloid leukemia
Schematic image, showing the R-loop resolution by REXO5 (left) and the inhibition of R-loop resolution by REXO5 mutation (right). Credit: Leukemia (2024). DOI: 10.1038/s41375-024-02362-z A key gene that could enhance the treatment success rates of chronic myeloid leukemia (CML) has been discovered by researchers. Professor Hongtae Kim and his research team in the Department of Biological Sciences...
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Researchers discover new ways to ‘turn off’ receptor involved in inflammatory diseases
Adam Oken, B.A., a graduate student in the Mansoor lab, points to a cryo-EM map (blue) and its corresponding model (mostly yellow and other colors). The cryo-EM map is generated after processing data obtained from the “advanced imaging techniques” and it directly corresponds to the position of atoms in 3D space. The assembly of thousands...
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Childhood sleep disturbance linked to suicidal thoughts and behaviors two years later
Association between sleep disturbance at age 10 years and suicidal behavior at age 12 years. Credit: JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.33734 Kids who have a lot of difficulty sleeping are at heightened risk for developing suicidal thoughts and behaviors as they enter adolescence, a new Stanford Medicine-led study found. The research, published recently in JAMA Network Open, tracked more...
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Promising cell therapy offers hope for relapsed or refractory T-cell leukemia
Antileukemia activity of anti-CD7 PEBL-CAR T cells. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03228-8 A new cell therapy, targeting CD7 in leukemia cells, gives a potentially effective treatment for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have exhausted all standard treatment options. Published in the journal Nature Medicine on 3 September 2024, the study highlights the effectiveness of a new chimeric...