Doug Brunk December 30, 2024 012 Added to Email Alert For over 200 years, researchers have been captivated by axolotl salamanders (Ambystoma mexicanum) and their remarkable regenerative abilities, seeking to uncover secrets that could revolutionize regenerative medicine, including the scarless healing of wounds. “The axolotl salamander is the most studied animal ever in science for...
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Scientists design nanoparticle drug delivery system for levodopa
System improves motor function in Parkinson’s mice by Lindsey Shapiro, PhD | December 30, 2024 Scientists have developed a nanoparticle drug delivery system designed to enhance brain delivery of levodopa, the mainstay treatment for Parkinson’s disease, while also lowering a type of cellular damage called oxidative stress that’s implicated in the neurodegenerative condition. Advertisement The system was able to improve...
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Norovirus cases are rising in the U.S., CDC data shows
Center for Disease Control headquarters is seen in Atlanta, Georgia. Photo: Nathan Posner/Anadolu Agency via Getty Images Cases of a highly contagious stomach bug are rising across the U.S., according to new data from the Centers for Disease Control and Prevention (CDC). Why it matters: Norovirus can cause ghastly bouts of vomiting and diarrhea as a result of inflammation...
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Preclinical study finds surges in estrogen promote binge drinking in females
Peer-Reviewed Publication Weill Cornell Medicine The hormone estrogen regulates binge drinking in females, causing them to “pregame” – consume large quantities of alcohol in the first 30 minutes after it’s offered, according to a preclinical study led by scientists at Weill Cornell Medicine. The study establishes–for what is thought to be the first time–that circulating...
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New Technique Maps Hundreds of Proteins Simultaneously within Cell Nuclei
Posted Today Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell nuclei simultaneously. The method, called ChIP–DIP (Chromatin ImmunoPrecipitation Done In Parallel), is a versatile tool for understanding the inner workings of the nucleus in different contexts, such as disease or development. A schematic describing the ChIP-DIP process. Image...
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Newly discovered mechanism reveals NAD’s role in aging and disease
by University of Bergen Proposed model for the cooperation of SLC25A51 and NMNAT3 to buffer cellular NAD+ fluctuations. Credit: Nature Metabolism (2024). DOI: 10.1038/s42255-024-01174-w UiB researchers are behind a new discovery that tells us how associated neurodegenerative diseases might develop. At the center of this discovery stands a molecule called NAD, or nicotinamide adenine dinucleotide. The results have been published in Nature...
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Recombinant Pertussis Booster Offers Lasting Immunity
Edited by Shreyasi Asthana December 23, 2024 90 TOPLINE: A booster dose of recombinant pertussis vaccines provides sustained immunity in adolescents and young adults even after 5 years, with pertussis toxin (PT)–neutralizing antibody levels remaining 2.5- to 3-fold higher than prevaccination levels. METHODOLOGY: TAKEAWAY: IN PRACTICE: “The 5-year persistence of neutralizing anti-PT antibodies at levels...
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AI spots heart conditions before sufferers have symptoms
Artificial intelligence has been trained to identify those at risk of developing atrial fibrillationTelegraph Reporters Related Topics 28 December 2024 7:47am GMT 28Gift this article free Artificial intelligence is being used to find people with heart conditions before they even have symptoms. In an ongoing trial, a ground-breaking tool scours GP records for “red flags” which...
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Bidirectional association found between rheumatoid arthritis, COPD
by Elana Gotkine There is a bidirectional association between rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD), according to a review published online Dec. 1 in Frontiers in Immunology. Meijiao Wang, from the Zhejiang Chinese Medical University in Hangzhou, and colleagues examined the bidirectional association between RA and COPD in a systematic review of the...
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Breakthrough treatment flips cancer cells back into normal cells
By Michael Franco December 26, 2024 This generative image shows the concept the researchers proved of turning a cancerous cell back into a healthy cell View 1 Images Working with a line of colon cancer cells, Korean researchers figured out a way to throw a few genetic switches to cause the cells to revert back to...