by Mayo Clinic Credit: CC0 Public DomainEncephalitis is a disease that involves the inflammation or swelling of the brain. It can happen because of infections or immune system problems, and early treatment is important. That’s why Sarosh Irani, B.M.B.Ch., a neurologist and researcher at Mayo Clinic in Jacksonville, Florida, says it’s essential to raise awareness. “A...
by Lauren Quinn, University of Illinois at Urbana-Champaign Finasteride decreases plaque size and macrophage content in Ldlr-/- mice. Four-week-old male Ldlr-/- mice were fed Western diet with increasing doses of finasteride for 12 weeks. Two days before tissue harvesting, mice were injected with EdU to track monocyte trafficking into the atherosclerotic lesions. (A) En face visualization...
by Case Western Reserve University Phenotypic screen identifies HDAC3 as a regulator of pathological reactive astrocytes. a, Scatter plot of primary screen results displayed as percent GBP2 positive, normalized to reactive astrocyte plus vehicle controls for all nontoxic chemicals. Validated hit chemicals colored in blue. The dashed blue line represents the hit cut-off at a ≥90%...
by Jim Schnabel, Cornell University Graphical Abstract. Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine’s mechanism of action has been unclear. Now, researchers at the Jill Roberts Center...
by University of Gothenburg Credit: CC0 Public DomainResearchers from from the University of Gothenburg have developed an ultra-sensitive blood test that reflects brain damage after acute ischemic stroke—and also predicts functional outcome. This is a discovery that is expected to be of great significance in the future. The findings are described in the journal Neurology. The...
by Sarah Wallwork and Lorimer Moseley, The Conversation Credit: Kindel Media from PexelsBack pain is common. One in 13 people have it right now and worldwide a staggering 619 million people will have it this year. Chronic pain, of which back pain is the most common, is the world’s most disabling health problem. Its economic impact...
Reports and Proceedings KAROLINSKA INSTITUTET ANDERS KJELLBERGCREDIT: MARTIN STENMARK High-dose pressurized oxygen can stress out old immune cells, leaving behind a younger, better functioning immune system. It helped with acute COVID, and now Anders Kjellberg is testing the method for post-covid as well. Hyperbaric oxygen therapy, giving patients 100 percent oxygen at a pressure corresponding...
Ludwig-Maximilians-Universitaet Muenchen (LMU)Sleep helps consolidate our memory of complex associations, thus supporting the ability to complete memories of whole events. Researchers had known for some time that sleep consolidates our memories of facts and episodic events. However, the research to date has concentrated mainly on simple associations – that is to say, connections between elements,...
by Massachusetts Institute of Technology Credit: CC0 Public DomainAny drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s not known which of those transporters they use to exit the digestive tract. Identifying...
Intravenous (IV) administration of the antiplatelet agent tirofiban for 72 hours was associated with a reduction in early neurologic deterioration compared with oral aspirin therapy in patients with acute ischemic stroke, in the randomized TREND trial. The results were presented at the International Stroke Conference 2024, held on February 7-9 in Phoenix, Arizona. Lead author...
