A new pathway in to preventing and treating Alzheimer’s? In the hunt for a cause and cure for Alzheimer’s disease and other neurodegenerative ailments, much attention has been focused on sticky proteins called beta-amyloid plaques that build up in the brain and cause nerve damage. A new potential target has been identified by researchers however, in...
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Life-saving breast cancer drug considered as 'the closest thing to a cure' set to be rejected for use on the NHS because of its cost
Breast cancer drug Palbociclib freezes the growth of aggressive tumours This delays the need for chemotherapy, enabling women to lead normal lives Rationing watchdog NICE rejecting the drug due to its £2,950 a month cost Drug will only be viewed as cost-effective if its price can be cut to £590 a month A revolutionary drug considered...
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'Helper cells' can turn toxic in brain injury and diseases
For many years, research on neurodegenerative diseases and spinal cord and brain injury has focused on damage to nerve cells, or neurons. Now, a new study of astrocytes – a type of cell that surrounds and supports neurons – finds that there is a subtype that can turn rogue and kill neurons, instead of helping...
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Genetic defect found to cause disease in multiple organs
New research from Queen Mary University of London has identified a novel syndrome in patients with kidney and adrenal disease New research from Queen Mary University of London (QMUL) has identified a novel syndrome in patients with kidney and adrenal disease. The research, published in the Journal of Clinical Investigation, identified defects in a novel gene...
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Sickle cell trait may confound blood sugar readings among African-Americans
The test and the traitA new study in JAMA finds that HbA1c tests underreport a key blood sugar measure in African Americans with sickle cell trait. A routine diabetes test produces lower blood sugar readings in African-Americans with sickle cell trait than in those without, potentially leading patients to remain untreated or with a mistaken...
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Vitamin D discovery could prove key to new treatments for metabolic disorders and certain cancers
A team led by Motonari Uesugi, professor and deputy director of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), found that a vitamin D metabolite known as ’25-OHD’ inhibits proteins that regulate lipid production. Those proteins, called sterol regulatory element-binding proteins (SREBPs), cannot then stimulate expression of lipid-producing genes. “To our knowledge, this is the...
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The breakthrough prostate test ALL men must ask for: 'Game-changing' scan saves you a painful procedure, but when will YOUR hospital get up to speed?
Chris Kitcher vividly recalls the moment he was diagnosed with prostate cancer He had been showed his two tumours on a screen, rather than needing a biopsy Chris was one of the first to try the new mpMRI scan, a new, pain-free cancer test Still, only 50 per cent of hospitals have the technology to...
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Hand-grip test can indicate decline in physical function of Parkinson’s patients
A basic hand-grip test has proven to be a reliable tool to monitor the decline of patients with Parkinson’s diseases. UBC researchers Jenn Jakobi and Gareth Jones, both Health and Exercise Sciences professors at UBC’s Okanagan campus, recently completed a study that examined the methods used to monitor the progressive advancement of Parkinson’s disease (PD)—a degenerative...
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Biggest Breast Cancer Breakthrough: Map Links Breast Cancer Cell Shape And Genes To Disease Outcomes
Cell Shape-Gene Network Can Predict Cancer Outcome Scientists at the Institute of Cancer Research in London took a closer look at cell shapes in millions of imaging scans of more than 300,000 breast cancer cells and information for about 28,000 genes. They discovered that the changes in cell shape, which can result from physical pressures...
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How are calluses and throat cancer related?
Many of us develop calluses at one point or another, but for some people calluses and corns can become severe and highly inconvenient. In some rare cases, extreme thickening of the skin is a symptom of a particular form of esophageal cancer. New research investigates the link between foot calluses and cancer of the esophagus...