Abstract Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible airway inflammation; currently, there is no effective or curative treatment and the main goals of COPD management are to mitigate symptoms and improve patients’ quality of life. Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung...
Author: admin
Post
Spherical biodegradable carriers support scalable and cost-effective stem cell expansion and bone formation
Stem cells (red) on polycaprolactone-based microcarriers. Bone tissue engineering is theoretically now possible at a large scale. A*STAR researchers have developed small biodegradable and biocompatible supports that aid stem cell differentiation and multiplication as well as bone formation in living animal models. Mesenchymal stem cells self-renew and differentiate into fat, muscle, bone, and cartilage cells, which makes them...
Post
Stem Cells Applications in Regenerative Medicine and Disease Therapeutics
Abstract Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by...
Post
Cancer cells disguise themselves by switching off genes, new research reveals
Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body. In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a...
Post
Anti-cancer drug gets a boost when combined with antirheumatic
The figure shows a close-up of the histone protein region of a nucleosome core particle in which two different drugs (auranofin and RAPTA-T) are bound. Scientists at EPFL and NTU have discovered that combining an anticancer drug with an antirheumatic produces improved effects against tumors. The discovery opens a new path for drug-drug synergy....
Post
Deworming pill may be effective in treating liver cancer
Metastatic hepatocellular carcinoma. Hepatocellular carcinoma (HCC), a cancer associated with underlying liver disease and cirrhosis that often only becomes symptomatic when it is very advanced, is the second leading cause of cancer deaths around the world, and yet it has no effective treatment. As with other conditions without treatments, the data that scientists need...
Post
Immunologic changes point to potential for clinical investigation of combination immunotherapy for deadly kidney cancer
Immunologic changes observed in an early study of patients with metastatic renal cell carcinoma (MRCC) raised the possibility for a larger clinical study of combination immunotherapy, according to findings reported by researchers at The University of Texas MD Anderson Cancer Center. The results of an open-label pilot study comparing combinations of anti-PD1 (nivolumab) alone, or...
Post
The ‘triple threat’ cancer capsule that can navigate itself towards tumours before exploding and releasing drugs
The drug is wrapped in a microcapsule that can navigate towards cancer cells Millions of these tiny capsules could be injected into the bloodstream The outer layer of the capsule would prevent damage to healthy tissue Using an ultrasound machine, doctors could trigger the microcapsules to rupture when they reach a solid tumor, releasing the...
Post
Antibody is effective against radiation-induced pulmonary fibrosis
Radiation therapy is part of the treatment regimen for about two thirds of cancer patients today. Radiotherapy is well tolerated in most cases, but it can also lead to damage in healthy tissues that are also irradiated. One debilitating side effect is radiation-induced fibrosis. Fibrosis is a process of scarring by which healthy tissue is...
Post
Scientists find surprising impact of junk DNA and RNA in cancer
Killer T cells surround a cancer cell. “Human satellite II,” an exceptionally high-copy but unexplored sequence of the human genome thought of as “junk DNA,” has a surprising ability to impact master regulators of our genome, and it goes awry in 50 percent of tumors, according to a new study published in Cell Reports by scientists...