Early dementia is typically associated with memory and thinking problems; but older adults should also be vigilant about hearing and communication problems, suggest recent findings in a joint Baycrest-University of Memphis study. Within older adults who scored below the normal benchmark on a dementia screening test, but have no noticeable communication problems, scientists have discovered a new potential...
Author: admin
Post
Researchers develop low-cost test to evaluate muscle health
Brad Willingham, a kinesiology doctoral student at the University of Georgia, holds an accelerometer in his lab in the UGA Ramsey Center. When used in conjunction with a device that uses low-level electronic pulses to make muscles move, the …more A new, non-invasive test developed by researchers at the University of Georgia shows how exercise...
Post
Researchers identify a new way to promote tissue regeneration
Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs. In a new study published in the journal Stem Cells, a team...
Post
The molecular underpinnings of T cell exhaustion
Prolonged overactivity of killer T cells summoned to a tumor or infection site can render them useless to dispatch invaders, a cellular state immunologists call “exhaustion.” Credit: National Institutes of Health One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of...
Post
Drug combination delivered by nanoparticles may help in melanoma treatment
Gavin Robertson, professor of pharmacology, pathology, dermatology, and surgery; director of the Penn State Melanoma and Skin Cancer Center and member of Penn State Cancer Institute, works with associates in the Melanoma Center. The first of a new class of medication that delivers a combination of drugs by nanoparticle may keep melanoma from becoming resistant...
Post
‘Google Earth’ for tumours could change cancer diagnostics and drug testing forever
This entry is part 12 of 16 in the series Grand Challenge Think of a tumour like a rapidly growing city within a patient’s body. Doctors can scan the patient to locate the tumour, much like a satellite can scan the earth and map its cities. And scientists can get a sense of the tumour at...
Post
Leukemia drug fends off cancer for a decade, study shows
The cancer drug Gleevec The cancer drug Gleevec appears to keep chronic myeloid leukemia at bay a decade into treatment — with no signs of additional safety risks, a new study finds. Gleevec — known generically as imatinib — was hailed as a “wonder drug” when it was introduced in 2001 for treating chronic myeloid leukemia (CML)....
Post
Castration-resistant Prostate Cancer Cell Growth Impeded by Endostatin
BIRMINGHAM, Ala. – Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options. University of Alabama at Birmingham researchers have discovered that endostatin, a naturally occurring protein in humans, can significantly decrease proliferation of castration-resistant prostate...
Post
Scientists stimulate immune system, stop cancer growth
Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system’s natural cancer-killing T-cells and caused primary tumors and metastatic tumors in the liver to shrink. A chemical found in tumors may help stop tumor growth, according to a new study. Researchers at the University of Illinois at Chicago...
Post
Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor...