INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Identifying genetic risk factors for Alzheimer’s disease is essential if we are to improve our understanding and treatment of it. Progress in human genome analysis along with genome-wide association studies[ are now leading to major advances in the field. Researchers in Europe, the US and...
Category: <span>Alzheimer’s</span>
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Loss of neurons, not lack of sleep, makes Alzheimer’s patients drowsy
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO The lethargy that many Alzheimer’s patients experience is caused not by a lack of sleep, but rather by the degeneration of a type of neuron that keeps us awake, according to a study that also confirms the tau protein is behind that neurodegeneration. The study’s findings contradict the common...
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Half of older adults now die with a dementia diagnosis, up sharply from two decades ago
by University of Michigan Credit: Pixabay/CC0 Public Domain Nearly half of all older adults now die with a diagnosis of dementia listed on their medical record, up 36% from two decades ago, a new study shows. But that sharp rise may have more to do with better public awareness, more detailed medical records and Medicare...
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C/EBPβ/AEP pathway dictates both Alzheimer’s disease and longevity: Study
by Chinese Academy of Sciences Neuronal C/EBPβ escalation shortens the life span of mice, leading to neural excitation. Credit: SIAT Cognitive decline during normal aging is exacerbated in neurodegenerative disease including Alzheimer’s disease (AD). While it is not yet known exactly what causes AD, there are a number of risk factors that make a person...
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Promising Alzheimer’s drug may also improve memory in down syndrome and normal aging
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS A new study shows that a potential treatment for Alzheimer’s disease may also improve cognitive function in people with Down syndrome. The drug sargramostim (GM-CSF, which stands for granulocyte-macrophage colony-stimulating factor) is the first to show memory improvement in Alzheimer’s patients in a phase II clinical trial. GM-CSF is a...
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Alzheimer’s leads to changes in the small blood vessels in the brain
by University of Oslo Earlier research has shown that several of the same risk factors behind the development of cardiovascular disease also can lead to Alzheimer’s. Pictured left to right: Shreyas B. Rao, Reidun Torp and Gry H.E. Syverstad Skaaraas. Credit: Carina Knudsen, UiO If the blood supply to your brain decreases, it can trigger...
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Researchers discover intake of FDA-approved drug modulates disease progression in Alzheimer’s disease model
by Indiana University School of Medicine Credit: Pixabay/CC0 Public Domain Indiana University School of Medicine researchers have found that niacin limits Alzheimer’s disease progression when used in models in the lab, a discovery that could potentially pave the way toward therapeutic approaches to the disease. The study, recently published in Science Translational Medicine, investigates how...
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Cases of cognitive decline in older people more than doubles in ten years
by University College London Credit: CC0 Public Domain The researchers set out to see if there had been an increase in the numbers of older people who were reporting their first concerns about memory loss or cognitive decline to their doctor and what their chances of developing dementia were after consultation. The study, published today...
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Study shows that intranasal Rx halts memory decay in experimental Alzheimer’s model
LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER New Orleans, LA – A research collaboration between scientists at LSU Health New Orleans and the Karolinska Institutet in Sweden has found that applying specialized pro-resolving lipid mediators intranasally arrested memory loss and brain degeneration in an experimental model of Alzheimer’s Disease (AD). The results are published in the Nature journal, Communications Biology,...
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A complete transcriptomic analysis of astrocytes in Alzheimer’s disease
Reviewed by Emily Henderson, B.Sc. Mar 18 2022 An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer’s patients and in people without diagnosed dementia. The study, published in Neurobiology of disease, highlights the...