by University of Leicester Credit: CC0 Public Domain A promising new approach to potentially treat Alzheimer’s disease—and also vaccinate against it—has been developed by a team of UK and German scientists. Both the antibody-based treatment and the protein-based vaccine developed by the team reduced Alzheimer’s symptoms in mouse models of the disease. The research is...
Repeated listening to personally meaningful music induces beneficial brain plasticity in patients with mild cognitive impairment or early Alzheimer’s disease, a new study by researchers at the University of Toronto and Unity Health Toronto suggests. Changes in the brain’s neural pathways correlated with increased memory performance on neuropsychological tests, supporting the clinical potential of personalized,...
Researchers leading a worldwide clinical trial aimed at finding treatments for Alzheimer’s disease are modifying an arm of the trial to evaluate a combination of drugs targeting two brain proteins: amyloid and tau. The trial – known as the Tau Next Generation Trial (Tau NexGen) – originally was announced with a focus on drugs that...
by Indiana University School of Medicine Credit: CC0 Public Domain When immune cells move throughout the brain, they act as the first line of defense against viruses, toxic materials, and damaged neurons, rushing over to clear out them. Researchers at Indiana University School of Medicine have been investigating how these immune cells in the brain—microglia—relate...
by Georg Meisl, The Conversation Credit: Yurchanka Siarhei/Shutterstock Alzheimer’s disease and other types of dementia affect more than 55 million people worldwide. But the development of effective treatments and cures is progressing slowly. To some extent, this is because we still don’t understand enough about what causes the disease and drives its progression. Myself and my...
by University of Cambridge Credit: Pixabay/CC0 Public Domain For the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer’s disease and found that it develops in a very different way than previously thought. Their results could have important implications for the development of potential treatments. The...
UT SOUTHWESTERN MEDICAL CENTER IMAGE: JOACHIM HERZ, M.D. CREDIT: UT SOUTHWESTERN MEDICAL CENTER A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing...
Pauline Anderson A new noninvasive procedure is safe and effective for treating patients with mild Alzheimer’s disease (AD), new research suggests. Clinicians monitor a trial patient with AD undergoing low-intensity focused ultrasound. The approach uses MRI-guided low-intensity focused ultrasound (FUS) and injected microbubbles to temporarily open the blood-brain barrier (BBB). In a small group of patients, the...
IMAGE: INRS PROFESSOR CHARLES RAMASSAMY, SPECIALIST ON ALZHEIMER’S DISEASE, DOCTORAL STUDENT MOHAMED RAÂFET BEN KHEDHER AND POSTDOCTORAL STUDENT MOHAMED HADDAD. CREDIT: INRS Research conducted by the Ph.D student Mohamed Raâfet Ben Khedher and the postdoctoral researcher Mohamed Haddad of the Institut national de la recherche scientifique (INRS) has shown that an oxidation-antioxidant imbalance in the blood...
By Megan Molteni Oct. 11, 2021 Reprints ADOBE Ageneric drug used widely to treat swelling associated with hypertension and heart failure showed hints in early research that it may also prevent the devastating brain damage of Alzheimer’s disease, a surprising twist that suggests scientists have a lot more to learn about the root cause of the...
