by Massachusetts General Hospital A potential blood-based biomarker for Alzheimer’s and other neurodegenerative diseases seems even more promising thanks to new research from a Massachusetts General Hospital-led study. According to this team’s work, neurofilament light chain (NfL) has great potential as a biomarker for early detection of Alzheimer’s disease and could be also useful for...
New imaging technology allows scientists to see the widespread loss of brain synapses in early stages of Alzheimer’s disease, a finding that one day may help aid in drug development, according to a new Yale University study. The research, published May 13 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, compared the density...
by Brian Burns, Massachusetts General Hospital For the first time, using a mouse model of Alzheimer’s disease, scientists have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain. This relationship was previously documented in cell culture, but seeing this phenomenon in living mice makes it more likely...
CREDIT: PROFESSOR MI HEE LIM, KAIST Sometimes the most complex problems actually have very simple solutions. A group of South Korean researchers reported an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents against neurodegenerative disorders. The team developed redox-active aromatic molecular reagents with a simple structural composition that can simultaneously...
Asmall 3D version of the human brain develops key features of Alzheimer’s disease when it is infected with a virus that causes cold sores, scientists reported on Wednesday, adding to the evidence that this most common form of dementia can be caused by a common microbe. The new research, published in Science Advances, is the...
BOSTON (May 5, 2020)–Older adults who consumed small amounts of flavonoid-rich foods, such as berries, apples and tea, were two to four times more likely to develop Alzheimer’s disease and related dementias over 20 years compared with people whose intake was higher, according to a new study led by scientists at the Jean Mayer USDA...
By Nick Lavars While its exact causes are unknown, Alzheimer’s disease is commonly associated with clumps of toxic amyloid plaques in the brain, and researchers are continuing to understand the different components that help them take shape. Scientists at the University of Illinois at Urbana-Champaign have developed a new compound that attacks a number of...
by Karolinska Institutet Researchers at Karolinska Institutet in Sweden and the University of North Carolina in the USA have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was...
by University of Southern California New USC research reveals how APOE4, a genetic culprit for Alzheimer’s disease, triggers leaks in the brain’s plumbing system, allowing toxic substances to seep into the brain areas responsible for memory encoding and other cognitive functions. The damage is linked to future problems in learning and memory, even when the...
By Kenneth S. Kosik | Scientific American Research into the brain’s protein-disposal systems, electrical activity and three other areas looks promising Attempts to treat Alzheimer’s have floundered because scientists have spent too little time thinking deeply about the underlying biology of this ailment. Recent advances in understanding the brain’s protein-disposal systems, the role of inflammation,...
