September 4, 2018, National University of Singapore A transnational research team led by the National University of Singapore (NUS) has harnessed CURATE.AI, a powerful artificial intelligence (AI) platform, to treat a patient with advanced cancer, completely halting disease progression. This new development represents a big step forward in personalized medicine. Professor Dean Ho (left) and Mr...
Category: <span>Cancer</span>
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Achilles heel of anaplastic large-cell lymphoma (ALCL) cells identified
Anaplastic large-cell lymphomas (ALCL) are rare cancers of the white blood cells. New research from the international ERIA consortium, led by scientists in Vienna, has now shown that the same signaling pathway is essential to the growth of cancer cells in various forms of ALCL: TYK2 (tyrosine kinase 2, an important component of the immune system) prevents...
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Scientists identify weak point in deadly eye melanoma
Plant compound shuts down tumor growth WASHINGTON UNIVERSITY SCHOOL OF MEDICINE A natural plant compound exploits a newly identified Achilles’ heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School...
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Overlooked molecule might be key to how well cancer-fighting CAR-T cells work
A mostly overlooked component of CAR-T cells has a surprisingly strong effect on the cancer-fighting cells’ behavior, scientists reported on Tuesday, including in ways that might affect their safety and efficacy. The component is called the co-stimulatory domain, and the two CAR-T therapies approved last year to treat forms of leukemia and lymphoma — Yescarta...
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New test uncovers metabolic vulnerabilities in kidney cancer
DALLAS – Aug. 28, 2018 – In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention. IMAGE: DR. RALPH DEBERARDINIS AND HIS LAB MANAGER, JESSICA SUDDERTH,...
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UVA developing ‘two-headed arrow’ to kill ovarian cancer
Innovative approach may also destroy breast, prostate and other solid cancers UNIVERSITY OF VIRGINIA HEALTH SYSTEM A University of Virginia School of Medicine researcher is developing a two-fisted, antibody-based approach to destroy deadly ovarian cancer — an approach he believes could also be modified to kill breast, prostate and other solid tumors. IMAGE: THIS IS AN ARTISTIC INTERPRETATION OF THE ‘TWO–HEADED‘ ARROW UVA IS DEVELOPING TO DESTROY OVARIAN CANCER. The dual-pronged...
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Stem cells show promise as drug delivery tool for childhood brain cancer
The latest in a series of laboratory breakthroughs could lead to a more effective way to treat the most common brain cancer in children. Scientists from the University of North Carolina Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, and the UNC School of Medicine reported results from early studies that demonstrate how cancer-hunting...
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New cancer treatment uses enzymes to boost immune system and fight back
UT Austin Engineers develop new way to treat cancer using enzyme therapy UNIVERSITY OF TEXAS AT AUSTIN AUSTIN, Texas — Researchers at The University of Texas at Austin have developed a new approach to treating cancer using enzyme therapy. The enzyme, PEG-KYNase, does not directly kill cancer cells but instead empowers the immune system to...
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HKBU scholars in world-first breakthrough for difficult-to-treat breast cancer
Chemists at Hong Kong Baptist University (HKBU) have discovered the use of a metal compound that inhibits the enzyme closely associated with triple-negative breast cancer (TNBC), one of the most difficult forms of breast cancer to treat. The metal compound is found to inhibit the TNBC tumors with less toxicity in mice, thus their work...
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New way to break cancer’s vicious cycle
University of Toronto researchers have uncovered why some cancers grow faster than others. The team led by Liliana Attisano, Professor in U of T’s Donnelly Centre for Cellular and Biomolecular Research, has identified a protein called NUAK2, which is produced by cancer cells to boost their proliferation and whose presence in tumours is associated with poor disease prognosis....