Megha Padi, Ph.D., of the UA Cancer Center has developed a method for probing the genetic underpinnings of cancer and other diseases, which could lead to better treatments TUCSON, Ariz. – Recent headlines have cast suspicion on social network analysis, which can mine data from the internet to target advertisements or potentially influence elections. But what...
Category: <span>Cancer</span>
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New CAR T case study shows promise in acute myeloid leukemia
First time AML patient in remission nine months following CAR T cell therapy and a bone marrow transplant H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE TAMPA, Fla. – Chimeric Antigen Receptor T-cell therapy, also known as CAR T therapy, was named the biggest research breakthrough of 2017 by the American Society of Clinical Oncology. The personal gene...
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Study offers new approach to starve p53 deficient tumors
Brooke Emerling, Ph.D., is an Assistant Professor in Cancer Metabolism and Signaling Networks at Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California. Credit: Sanford Burnham Prebys Medical Discovery Institute One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete...
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Targeting molecules called miR-200s and ADAR2 could prevent tumor metastasis in patients with colorectal cancer
Researchers at SBP target miR-200s and ADAR2 in regulating metastasis of colon cancer cells. Colorectal cancer is the third most common cancer worldwide and the third-leading cause of cancer-related deaths. The main cause of death in patients with colorectal cancer is liver metastasis, with nearly 70% of patients eventually developing a liver tumor. Recent research...
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Do prostate cancer cells have an Achilles’ heel?
Credit: University of Illinois at Chicago Researchers at the University of Illinois at Chicago describe new ways to selectively kill prostate cancer cells by exploiting the cells’ revved-up metabolism. They report their findings in the online journal, eLife. In prostate cancer, the loss of a tumor suppressor gene called PTEN is very common. Without a functional copy of...
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Why cancer cells go to sleep—the mystery of cancer dormancy
Cancer has always been thought of as something that grows rapidly and uncontrollably, but this view may be wrong. New evidence suggests that cancer alternatively uses the “accelerator” and the “brake” in order to survive. If you plot the growth of prostate cancer tumour progression over years, you get a graph that looks something like this: Figure...
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Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy
University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to the identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples...
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Protein responsible for Leukemia’s aggressiveness identified
(Boston)–Researchers have identified a protein critical for the aggressiveness of T-cell leukemia, a subtype of leukemia that afflicts children and adults. The identification of ubiquitin-fusion degradation 1 (UFD1) allows for better understanding what causes leukemia to progress and become highly aggressive and treatment-resistant, and may lead to a new treatment for this type of cancer. Leukemia...
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End of ageing and cancer? Scientists unveil structure of the ‘immortality’ enzyme telomerase
Making a drug is like trying to pick a lock at the molecular level. There are two ways in which you can proceed. You can try thousands of different keys at random, hopefully finding one that fits. The pharmaceutical industry does this all the time – sometimes screening hundreds of thousands of compounds to see...
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Metastatic cancer gorges on fructose in the liver
Discovery of metabolic reprogramming in metastatic cancer could lead to new therapies DUKE UNIVERSITY DURHAM, N.C. — Biomedical engineers at Duke University have demonstrated that metastatic cancer cells can reprogram their metabolism to thrive in new organs. Specifically, the research shows that cells originating from colorectal cancer change their dietary habits to capitalize on the high levels...