Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumors. This study, being published in the April 24 advance online edition of...
Category: <span>Cancer</span>
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Chromosomal Instability Drives Cancer Metastasis
Image: When a chromosomally unstable cell divides, its chromosomes can become disordered during anaphase (1). Errors in segregation can allow chromosomes to leak into the cytosol, where they form “micronuclei” (2), which trigger an inflammatory response in the daughter cell (3). This response can lead to metastasis. EDITOR’S CHOICE IN ONCOLOGY Aneuploidy—the presence of abnormal numbers...
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Promising cancer drug aces human clinical trials
A new cancer drug known as BLU-667 has moved through phase I human trials, and the results are promising. Taken orally, the drug targets what are known as RET-driven cancers, including types of thyroid and lung cancers, which are normally hard to treat. A new cancer drug, known as BLU-667, has shown promise in human...
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Beyond PD-L1: Taking away TIM3 and Tregs stops cancer regrowth after immunotherapy
Radiation treatment can boost the effectiveness of anti-cancer immunotherapy. Still, some patients fail to respond to this combination, and while the combination of radiotherapy and immunotherapy is very good at creating remission, it’s not very good at sustaining it. Now a University of Colorado Cancer Center study presented at the American Association for Cancer Research...
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New study discovers cancer-relevant protein shield
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES Researchers from the Novo Nordisk Foundation Center for Protein Research have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment. The new study has just been published in the internationally acclaimed...
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How advanced nanotechnology can improve cancer care
Tel Aviv University, Harvard University researchers discuss the untapped potential of targeted nanocarriers to revolutionize cancer therapy A new Tel Aviv University study addresses the challenges of nanoparticle-based cancer-targeting strategies. It also suggests ways of refocusing the collaborative work of cancer researchers and clinicians to move the field forward from “the bench” to the patients....
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Immunotherapy provides long-term survival benefit: Further evidence in lung cancer
European Lung Cancer Congress (ELCC 2018) Lugano-Geneva, 12 April 2018 – Further evidence that immunotherapy provides long-term survival benefit for patients with lung cancer was presented today at ELCC 2018 (European Lung Cancer Congress) in Geneva, Switzerland. (1) Researchers presented the three-year survival results of the randomized phase 2 POPLAR trial in second line, (2)...
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Multiple Myeloma Study Links More Than Three Dozen Genes to Disease
NEW YORK (GenomeWeb) – Researchers have identified 40 genes that can be disrupted in the early stages of multiple myeloma. While multiple myeloma is characterized by known recurrent chromosomal changes, how the disease first develops isn’t clear. In 2017, there were 30,280 new multiple myeloma cases in the US and 12,590 deaths due to the...
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Simultaneous chemo and immunotherapy may be better for some with metastatic bladder cancer
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE (New York, NY- April 11, 2018) –Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond...
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Cancer surgery can awaken tumor cells, but in mice a cheap pill stops metastasis
Drugs like Aspirin can prevent the immune system from letting down its anti-cancer guard, according to a study in mice.JOE RAEDLE/GETTY IMAGES Bottles of aspirin and ibuprofen won’t soon be carrying labels saying they reduce the risk of breast cancer recurrence after surgery, but that kind of cheap drugstore remedy stemmed metastasis in a startling...