A rare-stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the β3 integrin subunit (blue) and transcription factor Slug (brown). Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them...
Category: <span>Cancer</span>
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Diabetes drug and over-the-counter aspirin could improve the effectiveness of cancer treatment, reveal studies
Metformin may slow breast cancer growth and reverse treatment resistance Adding aspirin to a cancer drug could help combat tumors resistant to therapies These include pancreatic, lung and colorectal cancers, as well as melanomas A widely-used diabetes drug and over-the-counter aspirin could help boost the effectiveness of cancer treatments, two studies suggest. Research has found that metformin...
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Diabetes drug metformin inhibits multidrug-resistant breast cancer
The drug metformin, typically prescribed to treat type 2 diabetes, keeps breast cancer cells from developing multiple drug resistance (MDR) and can reverse MDR after it¹s appeared, according to a study published December 6, 2017 in the open-access journal PLOS ONE by Terra Arnason from the University of Saskatchewan, Canada, and colleagues. Previous studies have shown that...
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Nanoparticles home in on cancer stem cells in promising new therapy
The researchers developed nanoparticles (represented in black) that can specifically target cancer stem cells (yellow), delivering a drug that inhibits their ability to grow Nanoparticle drug delivery systems are a hot area in medical research at the moment. The ability to engineer particles that can enter a human body and transport a drug directly...
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Cell death linked to tumor growth in prostate cancer patients
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) The goal of any cancer treatment is to kill tumor cells. Yet, one little understood paradox of certain cancers is that the body’s natural process for removing dead and dying cells can actually fuel tumor growth. A new University of Michigan study identifies...
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Increased oral pathogens, decreased bacterial diversity predict precancerous stomach cancer lesions
Elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer, finds a new study led by New York University College of Dentistry (NYU Dentistry) and New York University School of Medicine. The findings, published in the November issue of the Journal of...
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Encouraging oxygen’s assault on iron may offer new way to kill lung cancer cells
Blocking the action of a key protein frees oxygen to damage iron-dependent proteins in lung and breast cancer cells, slowing their growth and making them easier to kill. This is the implication of a study led by researchers from Perlmutter Cancer Center at NYU Langone Health, and published online November 22 in Nature. Human cells contain...
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People willing to trade treatment efficacy for reduced side effects in cancer therapies
When choosing their preferred treatment, people with chronic lymphocytic leukemia (CLL) place the highest value on medicines that deliver the longest progression-free survival, but are willing to swap some drug efficacy for a reduced risk of serious adverse events according to a study published online in Blood Advances, a Journal of the American Society of Hematology (ASH). The...
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Study suggests colon cancer cells carry bacteria with them when they metastasize
(Medical Xpress)—A team of researchers working at Harvard University has found evidence that suggests a certain type of bacteria found in colon cancer tumors makes its way to tumors in other body parts by traveling with the metastasizing cells. In their paper published in the journal Science, the group describes their study of the bacteria and...
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Cancer breakthrough: Potential cure could be ready as early as next year
British scientists are developing an immune therapy based on blood cells from patients who have made “miracle” recoveries from the disease. They believe they have found a way to extract the cancer-killing immune cells from donor blood and then multiply them by the million. The team at King’s College London say they are excited by...