(HealthDay)—The 70-gene signature (GS) assay affects treatment decisions among physicians treating patients identified as being at intermediate risk with the 21-gene assay (21-GA), according to a study published online Oct. 26 in JAMA Oncology. Michaela Tsai, M.D., from the Virginia Piper Cancer Center in Minneapolis, and colleagues conducted a study involving 840 patients with early-stage breast cancer and...
Category: <span>Cancer</span>
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Cancer trial led by University of Minnesota Medical School’s Dr. Clark Chen shows promise
New data illustrates notable success in treatment of recurrent brain cancer MINNEAPOLIS – October 27, 2017 – New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients...
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Blocking enzyme in normal cells may impede pancreatic cancer, Penn vet team shows
Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer’s insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the...
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3-D ‘Scaffold’ Map to Help the Search for New Cancer Treatments
Researchers have produced the first three-dimensional (3D) map of a molecular ‘scaffold’ called SgK223, known to play a critical role in the development and spread of aggressive breast, colon and pancreatic cancers. The research was the result of a long-standing collaboration between Walter and Eliza Hall Institute researchers Dr Onisha Patel and Dr Isabelle Lucet...
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UA Cancer Center research team explores anti-breast cancer properties of soy
A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein, a component of soy foods, might suppress the development of breast cancer. The team’s most recent study, published in Current Developments in Nutrition, suggests genistein can protect BRCA1, a gene that plays a pivotal role in thwarting...
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Sight unseen: Gene expression reveals ‘hidden’ variability in cancer cells’ response to drugs
A study led by scientists from Harvard Medical School reveals “hidden” variability in how tumor cells are affected by anticancer drugs, offering new insights on why patients with the same form of cancer can have different responses to a drug. The results, published in Nature Communications on Oct 30, highlight strategies to better evaluate drug effectiveness and...
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Membrane perturbation through novel cell-penetrating peptides influences intracellular accumulation of imatinib mesylate in CML cells
Abstract Chronic myeloid leukemia is a stem cell disease with the presence of Philadelphia chromosome generated through reciprocal translocation of chromosome 9 and 22. The use of first- and second-generation tyrosine kinase inhibitors has been successful to an extent. However, resistance against such drugs is an emerging problem. Apart from several drug-resistant mechanisms, drug influx/efflux...
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Condition-specific gene co-expression patterns in cancer
Clemson’s Palmetto Cluster can complete trillions of mathematical operations per second. A Clemson University professor, an alumnus, a former IT staff member and two students have unveiled a computer software that can sort genes to better understand how they interact to cause disease. Published in the journal Scientific Reports in August, the software will help researchers...
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Researchers identify molecule that helps cancer stay alive, use antibody therapy against it
Kalipada Pahan, Ph.D. Certain cancer cells stave off their death with help from a particular molecule in a protein involved in the body’s immune system response, a research team at Rush University Medical Center has found. The researchers also have shown that neutralizing the molecule with a customized antibody therapy they developed can kill...
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Anti-myeloma agent opens for new treatment strategy
The tumour form multiple myeloma is very challenging to treat and is still considered incurable. In a recently published study in the scientific journal Oncotarget, researchers at Uppsala University show how inhibition of the protein BMI-1 could be used as a new strategy to treat the disease. Multiple myeloma is a type of blood cancer where immune cells grow in...