Cancer cells can reactivate a cellular process that is an essential part of embryonic development. This allows them to leave the primary tumor, penetrate the surrounding tissue and form metastases in peripheral organs. In the journal Nature Communications, researchers from the University of Basel’s Department of Biomedicine provide an insight into the molecular networks that regulate...
Category: <span>Cancer</span>
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Preclinical study in prostate cancer shows that virus-based drug candidate may improve anticancer vaccination
Andrei Gudkov, PhD, Senior Vice President of Basic Science and the Garman Family Chair in Cell Stress Biology at Roswell Park Cancer Institute. One of the most important areas of cancer research today involves efforts to expand the benefits of immunotherapy to more patients. Research conducted by scientists at Roswell Park Cancer Institute in...
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A rare disease inspires a new way to attack cancer
Postdoctoral fellow Ulla Gerling-Driessen, right, and her adviser, Carolyn Bertozzi, discuss their work on the NGLY1 molecule. Some of the most promising new treatments for blood cancers, drugs called proteasome inhibitors, have a problem: For reasons that researchers are still working to fully understand, cancer cells can build up a resistance to them. Now,...
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COLON CANCER: APC PROTEIN AFFECTS IMMUNITY BY PREVENTING PRE-CANCEROUS INFLAMMATION
Adenomatous polyposis coli (APC) is a gene whose mutations are associated with a rare, hereditary form of colorectal cancer known as familial adenomatous polyposis. Research led by scientists at the Institut Pasteur, CNRS and Inserm have recently demonstrated that mutations to this gene do not only lead to the emergence of colon polyps; they also...
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UT Health San Antonio researchers define mechanism that causes kidney cancer to recur
SAN ANTONIO (Oct. 23, 2017) ― New research from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) and U.S. Department of Veterans Affairs has identified the molecular mechanism that causes kidney cancer to resist drug treatment. The findings were published Oct. 19 in the journal Nature Communications. In normal cell functioning, nutrients...
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Gallbladder cancer: Pharmacist finds protein that drives tumor growth
Patients with gallbladder cancer often show few or no symptoms for long periods of time. As a result, the tumours are only detected at a late stage of the disease when treatment is often no longer possible. Working in collaboration with pathologists at the University of Magdeburg, Sonja M. Kessler, a research pharmacist in the...
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Scientists Discovered a “Kill Switch” That Destroys Any Cancer Cell
IN BRIEF A new study has pinpointed a natural mechanism that cells used to defend against cancer millions of years ago. It could provide a new means of advanced cancer treatment. SUICIDE MOLECULES A new study has established that RNA molecules, originally developed as a means of studying genes, can trigger a hidden mechanism that...
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How does excess weight drive breast cancer? Study sheds light
Obesity is a known risk factor for breast cancer, but precisely how does excess weight drive the disease? A new study has shed some light, revealing the process by which obesity increases the aggression of breast cancer cells. Researchers reveal how obesity may promote breast cancer metastasis. By studying mouse and human breast cancer tissue, researchers discovered...
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Major study of genetics of breast cancer provides clues to mechanisms behind the disease
MONTRÉAL, Oct. 23, 2017 /CNW Telbec/ – Seventy-two new genetic variants that contribute to the risk of developing breast cancer have been identified by a major international collaboration involving hundreds of researchers worldwide. The studies reported today in the journals Nature and Nature Genetics identified 72 common variants that predispose to breast cancer. Among these genetic regions some are specifically associated with...
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Lung cancer driver ALK-fusion found in melanoma
Melanomas caused by sun exposure have been matched with targeted treatments and immunotherapies, in many cases dramatically extending patients’ lives. However, there are other kinds of melanoma not related to sun exposure and because they are caused by different genetic changes, they are not susceptible to the same targeted treatments. This often leaves patients...