Scientists from the University of Surrey have developed ‘intelligent’ nanoparticles which heat up to a temperature high enough to kill cancerous cells – but which then self-regulate and lose heat before they get hot enough to harm healthy tissue. The self-stopping nanoparticles could soon be used as part of hyperthermic-thermotherapy to treat patients with cancer,...
Category: <span>Cancer</span>
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New hope of a treatment for aggressive T-PLL leukaemia
New hope of a treatment for aggressive T-PLL leukaemia. Until now, there has been no adequate treatment available for the rare and highly aggressive malignant blood disease T-PLL leukaemia. By screening blood samples from patients with haematological diseases, a team of doctors and researchers from MedUni Vienna and CeMM, led by haemato-oncologist Philipp Staber,...
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Ral signaling pathway in health and cancer
Abstract The Ral (Ras‐Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and...
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Suicide molecules kill any cancer cell
Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail-safe mechanism that may protect us from cancer. The mechanism—RNA suicide molecules—can potentially be developed...
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US regulators approve 2nd gene therapy for blood cancer
In this May 2016 file photo provided by Kite Pharma, cell therapy specialists at the company’s manufacturing facility in El Segundo, Calif., prepare blood cells from a patient to be engineered in the lab to fight cancer. On Wednesday, Oct. …more U.S. regulators on Wednesday approved a second gene therapy for a blood cancer, a...
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Leukemia: Cancer cells killed off with diabetes drug
Scientists may have found an innovative way to kill off cancer cells in acute myeloid leukemia, all the while preserving and regenerating healthy red blood cells. Researchers may have found a way to suppress leukemic cells (shown here) while preserving healthy red blood cells. The new study was carried out by researchers from the McMaster Stem Cell...
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Cancers Relapse by Feeding Off Immune Signals
In mice, the tumor cells are able to thwart the immune response that would kill them—but immunotherapy prevented the return of melanoma. After a seemingly successful cancer treatment, a few hearty cancer cells can remain in patients’ bodies, a dangerous persistence known as minimal residual disease (MRD). A new study, published today (October 16) in Cancer...
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Clinical trial hopes to provide less toxic treatment for prostate cancer
Dr. Gurkamal Chatta with his patient. Over the last decade, immunotherapy has emerged as one of the most promising and innovative fields in oncology. The goal of immunotherapy is to help a patient’s own immune system fight cancer. A major breakthrough came in 2010, when the FDA approved the first cancer-treatment vaccine, sipuleucel-T (brand...
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Drug yields high response rates for lung cancer patients with harsh mutation
A targeted therapy resurrected by the Moon Shots Program at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatment-resistant mutation. In a phase 2 clinical trial, the drug poziotinib has shrunk tumors by at least 30 percent in...
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A new compound targets energy generation, thereby killing metastatic cells
New approach is based on a surprising link between the energy generation system of sperm and cancer cells Cancer can most often be successfully treated when confined to one organ. But a greater challenge lies in treating cancer that has metastasized, or spread, from the primary tumor throughout the patient’s body. Although immunotherapy can be...