Scientists hope that by targeting specific protein, they will be able to develop treatments for patients with metastasized cancers resistant to chemotherapy and immunotherapy By RENEE GHERT-ZAND7 May 2023, 12:38 am Illustrative: Metastatic ovarian adenocarcinoma- Pleural fluid cell block (Yale Rosen via Wikimedia Commons) Researchers at Tel Aviv University have successfully used RNA nanodrugs to target...
by University of California, San Francisco Credit: Pixabay/CC0 Public Domain Transgender women keep their prostates even after gender-affirming surgery, but the extent to which they remain at risk of prostate cancer has been unclear. Now a first of its kind study led by UC San Francisco has estimated the risk at about 14 cases per 10,000...
Cancer research has made big strides over the past few decades, leading to better prevention efforts, improved treatment options, and longer survival. Despite the significant progress, there is still a lot of work to do. In the latest issue of Cell, cancer specialists from across the globe provided their take on the big questions worth exploring in cancer research...
by Northwestern University Credit: Pixabay/CC0 Public Domain A major impediment to treating the deadly brain cancer glioblastoma has been that the most potent chemotherapy can’t permeate the blood-brain barrier to reach the aggressive brain tumor. But now Northwestern Medicine scientists report results of the first in-human clinical trial in which they used a novel, skull-implantable ultrasound...
Lei Lei WuNews Reporter In an early cut of data, Johnson & Johnson said Sunday afternoon that seven of eight bladder cancer patients who received its experimental bladder cancer treatment — a decades-old chemotherapy delivered in a device which its developers call “the pretzel” — saw their tumors go away. The Phase II study, known...
by CNRS CD44 mediates copper uptake. a, Experimental setup used to generate inflammatory monocyte-derived macrophages (MDMs). b, Flow cytometry of CD44 in MDMs. Data are representative of n = 13 donors. AU, arbitrary units. c, ICP-MS of cellular copper in MDMs (n = 9 donors). d, ICP-MS of cellular copper in aMDMs with short interfering RNA (siRNA) knockdown of indicated receptors and transporters (n = 6 donors)....
M. Alexander Otto, PA, MMS April 18, 2023 The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide,...
by Children’s Hospital of Philadelphia Representative images from subject 3 who had both measurable and MIBG-evaluable neuroblastoma and an overall central radiology reviewed PR from cycles 3 through 8, and PD at cycle 11. This patient enrolled with a history of progressive disease on a prior irinotecan-containing regimen. The left top panel shows the baseline 3.5-cm...
COLD SPRING HARBOR LABORATORY IMAGE: MOUSE PANCREAS CELLS WITH HIGH LEVELS OF THE PROTEIN SRSF1; CSHL PROFESSOR ADRIAN KRAINER FOUND THAT MICE WITH HIGH LEVELS OF SRFS1 TEND TO EXHIBIT INTRAEPITHELIAL NEOPLASIA—A KNOWN PRECURSOR TO THE MOST COMMON FORM OF PANCREATIC CANCER. CREDIT: KRAINER LAB/COLD SPRING HARBOR LABORATORY Pancreatic ductal adenocarcinoma (PDAC) is the most...
by King’s College London CSPG4 expression in malignant melanoma and normal tissues. a CSPG4 mRNA expression, derived from RNAseq data, across cell lines of different cancer cell types. n represents the number of cell lines (data from Cancer Cell Line Encyclopedia (CCLE), portals.broadinstitute.org/ccle, n = 56, n = 59, n = 26, n = 57, n = 28, n = 27, n = 48, n = 127, n = 41, n = 32, n = 26, n = 37, n = 8, n = 50, and n = 58, respectively) (p = 0.0156 and p ≤ 0.0001). b CSPG4 gene expression in tissues across cancer types (data and images from Human Protein...
