Targeting healthy cells that have been hijacked by cancer cells could help treat many different types of the disease, according to research* funded by Cancer Research UK and published in the Journal of the National Cancer Institute today (Thursday). Scientists found that targeting an enzyme known as NOX4 stops the action of a type of cell called...
Category: <span>Cancer</span>
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How specks of gold can help fight lung cancer: Precious metal found to increase effectiveness of drugs used to treat the disease
Tiny flecks of gold could be used in the fight against cancer, research suggests Study says it increased the effectiveness of drugs used to treat lung cancer cells Minute fragments, called gold nanoparticles, were encased in a chemical device Scientists at Edinburgh University have just completed a study and released data Tiny flecks of gold could...
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Increased α5β1 integrin could improve tumor cell-killing performance in geriatric patients
Research in the Journal of Leukocyte Biology suggests increased α5β1 integrin can improve tumor-killing behavior by CAR-T therapy in the aging population A new report in the Journal of Leukocyte Biology describes an important step toward developing cancer treatments involving the body’s immune system. Specifically, chimeric antigen receptor T cell (CAR-T) therapy involves collecting white blood cells...
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Cell mechanism discovery could lead to ‘fundamental’ change in leukaemia treatment
Researchers have identified a new cell mechanism that could lead to a fundamental change in the diagnosis and treatment of leukaemia. A team in the University of Kent’s pharmacy school conducted a study that discovered that leukaemia cells release a protein, known as galctin-9, that prevents a patient’s own immune system from killing cancerous blood...
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Researchers release first draft of a genome-wide cancer ‘dependency map’
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes upon which cancer cells from multiple types are strongly dependent for their growth and survival. Many of these “dependencies,” the...
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Long-sought mechanism of metastasis is discovered in pancreatic cancer
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power their ability to metastasize, or spread to distant sites in the body, newly published research reveals. The research, appearing online...
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Molecular hitchhiker on human protein signals tumors to self-destruct
Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found. Their research gives oncologists a better shot at overcoming the problems of drug resistance, toxicity to patients and a host of other barriers to consistently achieving successful gene therapy for cancer. It is...
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Study uncovers potential ‘silver bullet’ for preventing and treating colon cancer
In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential “silver bullet” for preventing and treating it. The findings may extend to ovarian, breast, lung, prostate and potentially other cancers that depend on the same mechanism for growth. Led by Massey’s...
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Drug combination shows better tolerance and effectiveness in metastatic renal cell cancer
A new cooperative research study including Norris Cotton Cancer Center’s Lionel Lewis, MB BCh, MD, finds that nivolumab plus ipilimumab therapy demonstrated manageable safety, notable antitumor activity, and durable responses with promising long term overall survival in patients with metastatic renal cell cancer (mRCC). The multi-institutional study known as the CheckMate 016 study evaluated the...
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Breaking the genetic resistance of lung cancer and melanoma
Researchers from Monash University and the Memorial Sloan Kettering Cancer Center (MSKCC, New York) have discovered why some cancers – particularly lung cancer and melanoma – are able to quickly develop deadly resistance to targeted therapies. Dr Luciano Martelotto, from the Monash University Faculty of Medicine, and his collaborators Dr Piro Lito and Yaohua Xue...