Laser light can be seen scattered by nanoparticles in a solution of the UTSW-developed nanovaccine. Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types. The nanovaccine consists of tumor antigens — tumor proteins that can be recognized by the immune system — inside a synthetic...
Category: <span>Cancer</span>
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Specialized blood vessels enhance tumor-fighting immunotherapy
Scientists from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments. The successful combination of these two therapies results in the growth of specialized vessels that deliver cancer-fighting immune cells to the tumor, potentially...
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Immune system can spot tell-tale change in identity of cancer antigens
A new study has identified novel mechanisms whereby T cells may be able to distinguish an emerging class of targets specifically increased on cancer cells. The study, carried out by researchers from the University of Birmingham and the University of Virginia, and published in Oncotarget, focuses on how the immune system recognises protein targets that are...
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Researchers Want to Regulate Your Genes to Help You Defeat Cancer
IN BRIEF Scientists are studying the ways to switch genes on and off as a means of battling cancer. This could eventually lead to highly personalized, down to the genetic level, treatments for cancer. Such methods could shut down cancer’s defences against medications. GETTING THE CODE TREATMENT Molecular insight into our own DNA is now...
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Th17 cells could facilitate wider clinical use of adoptive immunotherapy
CD8+ T cells and Th1 cells become exhausted and lose antitumor efficacy as they’re expanded for adoptive cell therapy. Th17 cells are resistant to degradation (senescence) and retain their antitumor efficacy, resulting in large numbers of …more Medical University of South Carolina (MUSC) investigators report that long-term expansion protocols for adoptive cancer immunotherapy do not...
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Immune system can spot tell-tale change in identity of cancer antigens
A new study has identified novel mechanisms by which T cells could distinguish an emerging class of targets specifically increased on cancer cells. The study was carried out by researchers from the University of Birmingham and the University of Virginia and published in Oncotarget. The study focuses on Phosphorylation– how the immune system recognizes protein...
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Meet The Bionic Thymus: The Artificial Organ For Pumping T Cells For Cancer Treatment
A team from the University of California, Los Angeles has successfully used an artificial thymus to turn blood stem cells into T cells. The UCLA researchers created the artificial organoid as a useful tool in reducing the time and cost of T cell immunotherapy for patients with a low count of white blood cells. Located...
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A potential cure for metastatic prostate cancer? Treatment combination shows early promise
In the past, all forms of metastatic prostate cancer have been considered incurable. In recent years, the FDA has approved six drugs for men with metastatic disease, all of which can increase survival. In a study published in Urology, researchers demonstrate for the first time that an aggressive combination of systemic therapy (drug treatment) with local...
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Clinical Trials of a New “Cancer Vaccine” Show That It May Actually Work
IN BRIEF A new personalized cancer vaccine has been designed to target 20 mutated proteins unique to each patient’s tumors. The vaccine seems to have prevented early relapse in 12 patients with skin cancer, keeping them cancer free for more than 2 years. A THERAPY FOR EACH PATIENT Cancer comes in many different forms, and it...
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Bionic thymus: Artificial organ for pumping T cells for Cancer Treatment
Researchers have successfully used an artificial thymus to turn blood stem cells into T cells. The UCLA researchers have created an artificial organoid as a useful tool in reducing the time and cost of T cell immunotherapy for patients with a low count of WBC’s. Thymus– the organ located near the heart makes T cells...