The U.S. Food and Drug Administration today granted accelerated approval to Bavencio (avelumab) for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy. This is the first FDA-approved treatment for metastatic MCC, a rare, aggressive form of skin cancer....
Category: <span>Cancer</span>
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Scientific discovery opens new possibilities for cancer and fibrosis treatment
Researchers from the Turku Centre for Biotechnology (BTK) in Finland have discovered that a cellular fuel sensor, known to control energy processes in the cells, is involved in the regulation of the contact of cells with their surrounding environment. This unexpected link could help scientists better understand life-threatening diseases, such as cancer and tissue fibrosis....
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Study provides path for new immunotherapy approaches to prostate cancer
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system, researchers at The University of Texas MD Anderson Cancer Center report in Nature Medicine. Based...
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Scientists discover mechanism that causes cancer cells to self-destruct
Many cancer patients struggle with the adverse effects of chemotherapy, still the most prescribed cancer treatment. For patients with pancreatic cancer and other aggressive cancers, the forecast is more grim: there is no known effective therapy. A new Tel Aviv University study published last month in Oncotargetdiscloses the role of three proteins in killing fast-duplicating cancer cells...
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Protein identified as potential druggable target for pancreatic cancer
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five-year survival rate. PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair...
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Researchers identify interaction among proteins that cause cancer cells to metastasize
Electron microscopic image of a single human lymphocyte. Researchers at Mayo Clinic have identified an interaction among proteins that allows cancer cells to grow and metastasize. They say the discovery may play a role in developing a better understanding of how tumors grow in a variety of malignancies, including breast, prostate, pancreatic, colon, lung...
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Researchers show p300 protein may suppress leukemia in MDS patients
MIAMI, March 27, 2017 – Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). The study was published in the journal Leukemia....
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PHD2 targeting overcomes breast cancer cell death upon glucose starvation
Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. B55α is one of the regulatory subunits of the PP2A phosphatase. This phosphatases has been associated to the control of many biological functions but the multiplicity of complexes that can be formed by the combination...
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Tethered nanoparticles make tumor cells more vulnerable
New strategy could improve performance of some immune-based drugs MIT researchers have devised a way to make tumor cells more susceptible to certain types of cancer treatment by coating the cells with nanoparticles before delivering drugs. By tethering hundreds of tiny particles to the surfaces of tumor cells in the presence of a mechanical force,...
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What’s to know about metastatic lung cancer?
While cancer may develop in one area of the body, it has the ability to spread to other areas. When cancer spreads in this way, it is said to have metastasized, and is known as metastatic cancer. Metastatic cancers are associated with the primary (or original) cancer. For example, lung cancerthat spreads to the liver is called...