T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor...
Category: <span>Cancer</span>
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The intestine has a reservoir of stem cells that are resistant to chemotherapy
These comprise a small group of passive stem cells -quiescent- that are activated when needed and have the capacity to produce any kind of intestinal cell. Quiescent cells are relevant for tissue regeneration and for participation in tumor development After Chemotherapy, these cells change their behaviour, become active and regenerate all cell types in the...
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Vitamin C can target and kill cancer stem cells, study shows
Cancer is currently one of the top killers worldwide, and the number of cancer cases is only expected to rise. Although there are a number of therapies available, most of them are toxic and cause serious side effects. New research examines the impact of the natural vitamin C on cancer cell growth. In a recent...
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Cancer breakthrough: Scientists discover how to kill ‘undruggable’ proteins using ‘the kiss of death’
Many cancers and Huntington’s are caused by stubborn proteins Ras and Myc No previous studies have been able to kill the ‘undruggable’ proteins A team at the University of Dundee forced molecules to bind to Ras and Myc In doing so, they successfully destroyed them – paving the way to a cure Scientists have discovered...
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Ultrafast detection of a cancer biomarker enabled by innovative nanobiodevice
Pioneering nanobiodevice can isolate cancer biomarkers quickly with high resolution Quartz-made Nanopillars of 250-nm diameter were arrayed inside nanoslit region of 100-nm high and applied for ultrafast microRNA extraction from nucleic acids mixture. Like DNA, ribonucleic acid (RNA) is a type of polymeric biomolecule essential for life, playing important roles in gene processing. Short lengths...
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Combination of ground-breaking treatments offer powerful new path for blood cancer therapies
Researchers at Monash University and Peter MacCallum Cancer Centre have identified for the first time how a new class of epigenetic drug engages with the immune system to kill off cancer cells, offering powerful new pathways for enhanced blood cancer therapies. BET-inhibitors are a relatively new class of drug which work to ‘switch off’ important...
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Stem cells make potential drug side effects personal
Researchers in Singapore have developed a way to use patients’ stem cells to see whether a cancer drug is safe for them In a promising development that strengthens the case for personalized cancer care, scientists in Singapore have demonstrated the possibility of predicting the potential for an individual to have adverse side effects to different drugs by first...
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A New Cancer Treatment Has Given Terminal Patients a Second Chance at Life
IN BRIEF Gene therapy has been shown in clinical trials to not just treat cancer, but possibly cure it. The treatments have risks — including death — so additional research is needed before they could become widely available. COULD THIS TREATMENT CURE CANCER? Despite the many advances in medicine over the last century, a cure...
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Supramolecular protein fishing with molecular baits
IBS researchers modified an anti-cancer drug to capture, purify a cancer-prone protein Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using ‘molecular bait’. Cancer, according to the American Cancer Society, affects 1 in 2 men and 1 in 3 women, with prostate and breast...
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Here’s How Google’s AI Helps Detect Cancer Via Deep Learning
Deep learning, a form of artificial intelligence (AI) where computers are taught to recognize patterns in huge datasets, can now be useful in identifying breast cancer. Google reported March 3, Friday, that it has achieved groundbreaking results in using AI to analyze thousands of cancer cell slides from a Dutch university and diagnose the common form...