Peer-Reviewed Publication Umea University image: Francesca Aguilo, associate professor at the Department of Molecular Biology at Umeå University and leader of the study. Credit: Mattias Pettersson A study led by Umeå University, Sweden, have made new discoveries about how stem cells develop and transition into specialised cells. The discovery can provide increased understanding of how...
Category: <span>Cancer</span>
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Metabolic syndrome factors linked to increased bowel cancer risk
Credit: Pixabay/CC0 Public Domain Metabolic disorders such as obesity, high blood pressure and non-alcoholic fatty liver diseases have been directly linked to an increased risk of developing bowel cancer, warn Flinders University researchers. Bowel, or colorectal, cancer is the second deadliest and fourth most common type of newly diagnosed cancer in Australia with more than 15,000 Australians...
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Failure in a CAR T cell trial could unlock multiple treatments for acute myeloid leukemia
AML exposure to cytokines results in CART-123 exhaustion. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03271-5 In the clinical battle against leukemia, recent breakthroughs in chimeric antigen receptor T cells (CAR T) have given patients and doctors an unprecedented weapon. CAR T cell therapy has demonstrated efficacy in treating B-cell malignancies, achieving high response rates and durable remissions. However,...
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New technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
A clonal competition assay showing populations of cells with different mutations. Depending on the mutation, each population of cells is stained a different color. Credit: Larissa Haertle / CNIO Not all cells within the same cancer are the same. They all have genetic errors that turn them into tumor cells, but these errors are not...
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DAPK3 emerges as a new regulator of migration of triple-negative breast cancer cells
Graphic representation of the functional role of DAPK3 in TNBC cells. Credit: PNAS Nexus (2024). DOI: 10.1093/pnasnexus/pgae401 Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone. They experience worse outcomes than patients with other...
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Epigenetic test could help predict efficacy of immunotherapy in multiple myeloma
Epigenetic characterization of PVR shows the correlation between promoter DNA methylation and expression. Credit: Leukemia (2024). DOI: 10.1038/s41375-024-02419-z Multiple myeloma is a type of blood cancer that appears mainly after the age of 60. Its incidence, therefore, increases with the aging of the population. In this pathology, the bone marrow, the porous structure within the bones that...
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Study shows cancer vaccine blocks tumor progression at early lesion stage
C A cancer vaccine that had little success in clinical trials for patients with advanced tumors could potentially have efficacy if administered earlier in the treatment cycle, according to a study from Vanderbilt researchers. The investigators demonstrated in a mouse model that the cancer vaccine can block tumor progression if administered when the lesions are at an...
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Discovery of key gene offers new hope in treating chronic myeloid leukemia
Schematic image, showing the R-loop resolution by REXO5 (left) and the inhibition of R-loop resolution by REXO5 mutation (right). Credit: Leukemia (2024). DOI: 10.1038/s41375-024-02362-z A key gene that could enhance the treatment success rates of chronic myeloid leukemia (CML) has been discovered by researchers. Professor Hongtae Kim and his research team in the Department of Biological Sciences...
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Early blood test can predict survival in men newly diagnosed with metastatic prostate cancer, clinical trial finds
A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest. It can help providers decide which patients should receive standard treatment versus who might stand to benefit from riskier, more aggressive new drug trials. The research, part of a Phase...
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Scientists discover that special immune cells stop metastatic cancer
Metastatic disease—when cancer spreads from the primary tumor to other parts of the body—is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to seed new tumors, it’s not well understood why some of these wayward cancer cells spawn new tumors—sometimes decades later—while others do not. Now, a...